Knowde Enhanced TDS
Identification & Functionality
- Chemical Family
- Animal Feed & Nutrition Functions
- Ingredients
- Sorbitol, Nicotinamide, Magnesium Sulfate, Calcium Pantothenate
- Technologies
Features & Benefits
- Animal Feed & Nutrition Features
- Product Highlights
L-carnitine is an amino acid, which is synthesized in the liver from methionine and lysine. L-carnitine regulates fatty acid metabolism. It is involved in the utilization of fatty acids (excessive deposition of fatty acids in the mitochondria can damage cells, especially cells of the liver, brain and myocardium). It removes the remaining fatty acids from the mitochondria, and then from the cells, and promotes their excretion through the kidneys. Carnitine indirectly stimulates the cells of the immune system by removing excess lipids, which have an immunosuppressive effect.
L-carnitine is also involved in energy metabolism because it is responsible for the transport of long-chain fatty acids into the mitochondria, which allows the body to use additional energy sources and increase energy status (energy metabolism of fatty acids occurs in the mitochondria through beta-oxidation; the mitochondrial membrane is permeable to short- and medium-chain fatty acids and impermeable to long-chain fatty acids), it also increases enzyme activity in the digestive glands and body weight.
Following oral administration, L-carnitine is fully absorbed with maximum serum levels being obtained in 3 hours. It remains within the therapeutic range for 9 hours. L-carnitine accumulates mainly in muscle tissue. It is slowly excreted in the urine and partially reabsorbed by the kidneys.
Sorbitol is an osmotically active ingredient involved in energy metabolism. It has a diuretic, detoxification, choleretic, antispasmodic effect.
Sorbitol is quickly absorbed, 80-90% of it is utilized in the liver as glycogen, 5% is deposited in the brain and skeletal muscle, 6-12% is excreted in the urine. Sorbitol is converted by the liver to fructose and then to glucose and glycogen in its metabolism. Partially sorbitol is used for emergency energy needs and the rest is deposited as glycogen.
Magnesium sulfate has anticonvulsant, antiarrhythmic, vasodilating, hypotensive, spasmolytic, weak sedative, choleretic, tocolytic action. It is a source of magnesium. Magnesium is involved in muscular excitement and neurochemical transmission. It prevents penetration of Ca2+ through the presynaptic membrane and reduces acetylcholine level peripheral nervous system (PNS) and central nervous system (CNS). Magnesium stimulates intestinal motility and food absorption.
Nicotinamide stimulates the synthesis of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are cofactors of many enzymes. Nicotinamide as NAD and NADP is involved in oxidation-reduction reactions providing the normal metabolic pathways. It is an important link in a series of reactions associated with the metabolism of lipids, proteins, amino acids and purines, tissue respiration, glycogenolysis, biosynthesis processes; it also normalizes lipoprotein blood level.
Calcium pantothenate is converted to pantethine in the body, which is a constituent of coenzyme A, which in turn is involved in the metabolism of lipids, carbohydrates, proteins. It participates in the oxidation and biosynthesis of fatty acids, acetylcholine, steroid hormones and mucopolysaccharides.
Cyanocobalamin is a growth factor. It is necessary for normal blood formation and erythrocyte maturation, synthesis of labile methyl groups, methionine, choline, and nucleic acids. Vitamin B12 has a strong lipotropic effect, prevents fatty liver infiltration. It is required for the synthesis and accumulation of proteins, provides an anabolic effect and stimulates the defense mechanism of the body. It is involved in protein synthesis and accumulation. It provides also an anabolic effect. Cyanocobalamin strengthens the immune system due to increased phagocytic activity of leukocytes and activation of reticuloendothelial system function.
Applications & Uses
- Markets
- Applications
- Animal Species
- Indications for Use
For the prevention of metabolic disorders and support of the health of farm animals and poultry during convalescence or stress period. Heptran increases appetite and feed conversion, improves metabolism, growth performance and meat quality, supports proper hepatic and renal functions, prevents fatty liver syndrome.
- Stress conditions (transportation, vaccination, diet change, heatstroke, first days of life, weaning).
- Convalescence period.
- Stimulation of growth, development and productive performance.
- Improving the quality of meat in poultry farming.
- Dosage and Administration
Solution for use in drinking water. Heptran may also be poured over feed rations.
The duration of treatment may be changed depending on the veterinarian's discretion and animal’s health condition.
Prolonged use, as well as repeated treatment, are not restricted.
The prepared solution should be refreshed every 48 hours.
Target Species Groups of Animals Maintenance Dose (Stress) Increased Daily Dose (Convalescence, intensive growth and productivity) Cattle, Horses
Adult 20 ml per animal daily for 5 - 7 days 50 ml per animal daily for 5 days Young 15 ml per animal daily 2 - 3 times a week 20 ml per animal daily for 5 days Sheep, Goats
Adult 3 ml per animal daily for 5 - 7 days 10 ml per animal daily for 5 days Young 1 ml per animal daily for 5 - 7 days 5 ml per animal daily for 5 days Dogs, Cats General Recommendations 0.1 - 0,2 ml per 1 kg body weight daily for 5 - 7 days 0.3 - 0.4 ml per 1 kg body weight daily for 7 days Poultry (Broiler chicks, Laying hens, Turkeys, Geese, Ducks, Ornamental birds)
General Recommendations 0.5 - 1.0 ml per 1 liter of drinking water daily for 7 days 1 - 2 ml per 1 liter of drinking water daily for 7 days Poultry farming:
Period Dosage First days of life 1 - 2 ml/L of drinking water for 2 - 5 days (depending on the state of health of chickens) During illness 1 - 2 ml/L of drinking water for 2 - 5 days Diet change 1 - 2 ml/L of drinking water for the period of feed change and adaptation to a new feed Beginning of egg-laying 1 - 2 ml/L of drinking water for 2 days every 3 - 4 weeks up to egg laying - peak Heatstroke 2 - 4 ml/L of drinking water for 1 - 4 hours in the morning and 1 - 2 ml/L of drinking water for 8 - 10 hours in the evening Other stress conditions 1 - 2 ml/L of drinking water for 1 - 3 days during and after stress Dosage to improve the quality of poultry meat (reducing fat infiltration), average daily gain, feed conversion rate:
Period Dosage Broilers 2 ml/L of drinking water for 5 days during the change in diet, then once a week up to slaughter Laying hens (egg-laying start) 1 - 2 ml/L of drinking water for 2 days every 3 - 4 weeks up to the egg - laying peak Laying hens (egg-laying peak) 2 ml/L of drinking water for 2 days every 2 - 3 weeks Fattening geese, ducks 4 ml per bird a day for the first 15 days of fattening - Drug Interactions
- Concurrent administration with tetracyclines is not recommended.
- Simultaneous administration with vaccines given via drinking water is not allowed.
- Withdrawal Period
Meat / Eggs / Milk: Zero days/hours.
Properties
- Active Ingredient
| Value | Units | Test Method / Conditions | |
| L-carnitine | 50.0 | g/l | — |
| Magnesium sulfate | 200.0 | g/l | — |
| Sorbitol | 220.0 | g/l | — |
| Cyanocobalamin | 30.0 | mg/l | — |
| Calcium pantothenate | 8.0 | g/l | — |
| Nicotinamide | 20.0 | g/l | — |
Regulatory & Compliance
Safety & Health
- User Warning
People with known hypersensitivity to any of the ingredients should avoid contact with the product. Dermal and ocular exposure should be avoided. In case of exposure rinse the skin and/or the eye with water.
Packaging & Availability
- Packaging Type
- Packaging
- Heptran is marketed in polymer cans of 10 L.
Storage & Handling
- Disposal
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
- Shelf Life
- Shelf life of the veterinary product as packaged for sale is 2 years.
- Shelf life after opening the immediate packaging is 30 days at the temperature between 3°C - 5°C (in a refrigerator).
- Do not use this veterinary product after the expiry date, which is stated on the label.
- Storage Conditions
Store in the original package between 0°C to 35°C, protected from light and moisture.
Keep out of the sight and reach of children.