Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Key Benefits of Bicobiome®
- Regulates sebum production in the scalp.
- Reduces desquamation and dandruff scales.
- Re-balances the scalp’s microbiome.
Applications & Uses
- Markets
- Application Format
- Hair Care Applications
- Use Level
- 1 - 2 %
- Applications
- Bicobiome® is used as cosmetic ingredient.
- Bicobiome® is a microbiome and skin restoring system. It improves aging and acne signs in mature skin and restores scalp health in volunteers with oily and dandruff scalp.
Properties
- Odor
- Characteristic
- Appearance
- Off-white Fluid
- Physico-Chemical Properties
- Microbiological Values
| Value | Units | Test Method / Conditions | |
| Size | 100 - 600 | nm | Ph. Eur. 2.9.31 |
| pH | 3.0 - 6.0 | — | Ph. Eur. 2.2.3 |
| Value | Units | Test Method / Conditions | |
| Yeasts and Molds Count | max. 100 | cfu/g | ISO 16212 |
| Pathogens | Absence | — | ISO 22717 |
| Aerobic Bacteria | max. 1000 | cfu/g | ISO 21149 |
Technical Details & Test Data
- Skin Delivery Design
Designed to provide a complete and gentle solution for scalp imbalance, the nanostructures of Bicobiome® incorporate three active ingredients to regulate excessive sebum production, promote a gentle keratolytic action removing dandruff scales and boost microbiome re-balance. In addition, Bicosome® nanostructures reinforce the skin barrier function after releasing the active molecules, preventing irritations, and maintaining a healthy scalp.
- Scalp Microbiome Balance and Dandruff Removal
Bicobiome® is a multi-active delivery system designed to work in four steps to re-balance oily scalp microbiome and remove dandruff
The skin microbiome is a complex ecosystem that collaborates in the protective function of the cutaneous tissue. Oily scalp imbalance commonly promotes microbiome dysbiosis, specially related with Malassezia spp. resulting in inflammation and dandruff. Bicobiome® is a multi-active delivery system that incorporates a combination of sebostatic, postbiotic and keratolytic agents that are target delivered in different levels of the scalp thanks to Bicosome® technology. Bicobiome® re-stablishes the scalp environment in four steps, after which the natural homeostasis is achieved by the scalp’s own natural processes. The sebostatic and anti-inflammatory agent, Niacinamide works in the follicle regulating oil and inflammation. The postbiotic Lactobacillus ferment promotes microbiome re-balance in the first layers of the skin. The skin barrier function is reinforced by the bicosomes that fill-up the lipid matrix and finally, Salicylic acid works in the skin surface promoting a mild desquamation to remove the dandruff, cleaning the environment for a healthier scalp function. The in vivo tests showed that Bicobiome® was effective in reducing sebum in 28%, dandruff in 47% and desquamation in 67% after 28 days of use. The variation of the fungal microbiome showed a decrease in the total of Malassezia spp., M. globosa and M. restricta individually and also in its ratio, which is associated by different researchers with a healthier scalp.
- Efficacy Studies
A scalp lotion containing 1% of Bicobiome® was used twice a day in 20 volunteers with oily scalp and a clinical score of dandruff of 2 or more (scale of 1 – 5) during 28 days. Different measurements were carried out at initial time 0 (control), 14 and 28 days.
1.Oily scalp regulation
The sebum in the scalp progressively reduced during the treatment. At the beginning of the study (day 0), black areas of sebum of the scalp could be observed in Sebufix® tapes. After 14 and 28 days the black areas greatly decreased, in a total of 28% with statistically significant differences to the initial values on day 0 (p value = 0.015).
Decrease in sebum amount as measured by Sebufix® in 20 volunteers (p value = 0.015).
Images of Sebufix® tape of a volunteer collected at 0 time and after 14 and 28 days of Bicobiome 1% lotion treatment.2. Reduction of dandruff and desquamation
The excess sebum on scalp is the primary cause of dandruff. Thus, it is reasonable to expect that if sebum in the scalp is reduced the dandruff also decreases. Indeed, in our study this effect was readily evidenced by three different techniques. The images of Corneofix® show the decrease of dandruff white flake areas and the microphotographs directly shows the scalp skin allowing for visualizing the reduction of desquamation. The global clinical evaluation concluded that the use of the Bicobiome® 1% lotion visually improved the scalp health (macrophotographs), reducing desquamation, dandruff, and sebum in 95% of the volunteers. As shown in the graphics below, the dandruff and desquamation decreased significantly by 47% and 67%, respectively (p values < 0.05).
Average reduction of dandruff in different experimental times (n=20, *p value = 0.0001).
Average reduction of desquamation at different experimental times (n=20, * p value < 0.05).
Images of Corneofix® collected at 0 and 28 days of the study.
Microphotographs of the scalp of a volunteer collected at 0 and 28 days of the study.
Scalp macrophotographs of a volunteer collected at 0 and 28 days of the study.
3 .Microbiome Re-balance
Malassezia spp. have been related to dandruff phenotypes, being the M. globosa and M. restricta highly associated with these conditions (Vijaya Chandra et al 2021). More and more researchers point out also to the relation between the decrease of the ratio between these two species and a healthy scalp (Saxena et al. 2018 and Rong Tao et al 2021). In our studies, the improvement of the dandruff condition of the volunteers also coincides with the decrease of these species and also their ratio. After the use of Bicobiome® 1% lotion a reduction of the total amount of Malassezia spp. was observed, as well as, the amount of M. globosa, and M. restricta specifically. The decrease in the ratio between M. restricta to M.globosa, associated with a healthier scalp, is calculated in 33% (p value < 0.05).
Amount of total Malassezia spp. analysed, before (Day 0) and after (Day28) treatment with Bicobiome® 1% lotion.
M. Restricta and M. Globosa amount before (Day 0) and after (Day28) treatment with Bicobiome® 1% lotion.
Decrease in the ratio M. Restricta/M. Globosa after treatment with Bicobiome® 1% lotion. (n=20, * p value < 0.05).
Storage & Handling
- Storage Information
Store the product tightly closed in a dry place at no more than 8ºC and protected from light. It is recommended to stir the full content of the container before use or fractioning to assure adequate homogeneity. Use soon after opening the package.