Knowde Enhanced TDS
Identification & Functionality
- Product Type
- Technologies
- Product Families
Features & Benefits
- Labeling Claims
- Ready-to-Use Product Features
- Benefits
The product was specially formulated to address the odor, staining, disinfection time and temperature and reuse issues associated with aldehyde-based products. Field trial results indicated a preference for RespiCide GP Disinfecting Solution over each test site’s currently used product.
- Features & Benefits
Effectiveness Disinfection in 5 minutes at 20°C. Bactericidal, Fungicidal, Virucidal, and Tuberculocidal.
Safety No aldehydes. Low level of active ingredient. Class III Toxicity Rating, requires only a precautionary statement of “Caution”.
User-Friendly Low odor. Non-staining. Sold as a concentrate. Diluted with tap water. Easily handled. Requires minimal storage space.
Liability Single use, no effectiveness monitoring records required - fresh solution per treatment.
Materials Compatibility Does not damage or stain rubber/plastic medical equipment. Does not contain surfactants. Easily rinsed with water, no retention of product. Does not fix protein to equipment.
Disposability Can be discarded without special precautions. No organic residues.
Cost Efficient Less than $2.00 per use-dilution gallon. No additional costs; i.e., effectiveness monitoring tests, fume hoods or heaters.
Applications & Uses
- Markets
- Applications
- Application Area
- Compatible Substrates & Surfaces
- Application Procedure
One gallon of disinfecting solution is prepared by adding 4 ounces of RespiCide GP Solution to 124 ounces of water followed by the addition of 1 heaping tablespoon of activator. Allow 15 minutes for RespiCide GP Disinfecting Solution to become effective before treating equipment. Disinfection is complete in 5 minutes at 20°C. Equipment is removed from the disinfecting solution, rinsed with water and allowed to air dry before being reused. The disinfecting solution is discarded and fresh solution is prepared for the next disinfection procedure.
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Microbiological Data
Objectives:
To test the microbiological effectiveness of RespiCide GP Disinfecting Solution using test methods required by the Environmental Protection Agency (EPA) for registration approval and in simulated use testing.
Test Method Test Organism (s) Kill Time at 20°C*
Quantitative Tuberculocidal Test Mycobacterium bovis 5 minutes EPA Virucidal Testing (DIS/TSS-7, November 1981)
Poliovirus Type 2 5 minutes Herpes simplex 1 5 minutes Coxsackie virus 5 minutes Rhino virus 5 minutes Cytomegalovirus 5 minutes Respiratory syncytial virus 5 minutes AOAC Use Dilution Test
Pseudomonas aeruginosa 5 minutes Staphylococcus aureus 5 minutes Salmonella choleraesuis 5 minutes AOAC Fungicidal Test Trichophyton mentagrophytes 5 minutes Simulated Use Test**
Pseudomonas aeruginosa 5 minutes Staphylococcus aureus 5 minutes * Efficacy testing was conducted on RespiCide GP Disinfecting Solution at 32:1 dilution.
** Simulated use testing was conducted on inoculated plastic breathing masks. Bacterial cells were dried onto the breathing masks at 37°C in vacuo. Treatment time was 5 minutes at 20°C. R.S. Tanner, Ph.D., Professor of Microbiology, “Activity of RespiCide GP Disinfecting Solution Against Pseudomonas aeruginosa and Staphylococcus aureus on Breathing Masks”, The University of Oklahoma, May 31, 2003.Conclusion:
Microbiological efficacy test results support the 5-minute effectiveness label claim for RespiCide GP Disinfecting Solution against the test organisms shown in the above table.- Material Compatibility
Objectives :
To evaluate materials compatibility behavior of rubber and plastic breathing equipment with RespiCide GP Disinfecting Solution in laboratory studies and field trials.
Procedures :
- The material compatibility of RespiCide GP Disinfecting Solution was evaluated by immersing a variety of rubber and plastic facemasks, tubing and connectors in the test solution for 3 hours, twice a day for twenty days at ambient temperatures, which is equivalent to at least 1,440 simulated disinfection cycles.
- The test samples were removed from the test solution, washed with tap water, air-dried and visually inspected for surface damage, color changes and assessed for odor by olfaction after each treatment.
- The results were compared with those obtained from identical sets of equipment exposed to tap water.
Field trial :
- RespiCide GP Disinfecting Solution was used in three sleep labs for 3.5 months to disinfect their rubber and plastic facemasks, tubing, canisters and connectors. Equipment contact time/treatment was a minimum of 5 minutes.
- Lab personnel noted appearance of equipment after each treatment. Patients reported any effect of treated facemasks on nasal passages, skin and eyes.
Results :
Both studies showed that RespiCide GP Disinfecting Solution did not alter the surfaces of any of the test equipment. Tubing, canisters and connectors remained unchanged in color. In the field trial, some mild yellowing or pink discolorations were observed with some facemasks but the discolorations did not become increasingly intense with additional cycles. In all cases, the change was not considered a negative and was reported to be less than they observed with their current disinfecting solution products. In the laboratory study only a silicon gel filled mask became yellowed after repeated cycles. A non-silicon gel masked remained unchanged during the entire 20 days. Extracts from the silicon gel mask were assessed for cytotoxicity, however no cytotoxicity was found (Grade=0).
Conclusion :
RespiCide GP Disinfecting Solution when used as directed does not produce any undesirable affects on the appearance, performance or odor properties of rubber and plastic respiratory equipment such as: facemasks, tubing, canisters and connectors.
- Toxicity Testing
Objectives :
To measure the oral and dermal toxicity and skin and eye irritation of RespiCide GP Disinfecting Solution. Testing was performed to determine the potential toxicological affects of exposure to RespiCide GP Disinfecting Solution.
Results:
Primary Dermal Irritation Non-irritating Acute Dermal Toxicity Dermal LD50 >2g/kg body weight
Ocular Irritation
Mildly irritating, Class III rating
Male-Oral LD50 4g/kg body weight
Female-Oral LD50 3.5g/kg body weight
Acute Oral Toxicity Overall-Oral LD50 3.75g/kg body weight
Skin Sensitization Non-sensitizing Cytotoxicity Non-cytotoxic (Score = 0)
Conclusion :
The results of the toxicity testing showed RespiCide GP Disinfecting Solution to be non-toxic. The product has a Class III Toxicity Rating, which requires only a precautionary statement of “CAUTION”.
- Product Comparision
Active Ingredient Chlorine Dioxide Mode of action Oxidant MEC1 (disinfection) 0.0005% (5 ppm)
Packaging Concentrate (128 gal/case)
Activator Yes Efficacy Disinfection 5 min at 20°C Sterilization NA Safety Statement Caution Surfactants None Recommended Use Single Use Effectiveness Test NA Materials Compatibility
Rubber/Plastic Good Metals NA Odor/Eye Irritation Minimal Staining (skin) No Conclusion :
RespiCide GP Disinfecting Solution is a safe, economical, low odor, non-staining, fast acting, and materials compatible disinfectant. RespiCide GP Disinfecting Solution offers benefits over products currently used to disinfect heat sensitive, reusable, non-critical medical equipment.
Packaging & Availability