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MicrobiomeX® is a first-in-class Flavobiotic® specifically designed to support gut health and immunity.



This unique complex combines active flavonoids from Citrus Sinensis (hesperidin >80%) and Citrus Paradisi (naringin >5%) to protect the gut barrier and leverage the gut microbiome’s potential.



MicrobiomeX® is effective in two ways: directly through its active metabolites (direct antioxidant and anti-inflammatory effect in the gut), and indirectly through a profound prebiotic effect.



MicrobiomeX® is supported by two clinical studies which demonstrated the following health benefits with a daily dose of 250 - 500 mg:



  • Prebiotic effect (increase in multiple beneficial species)
  • Improvement in SCFA profile (strong increase in butyrate)
  • Reduction of gut inflammation markers (calprotectin, NF-kB, TNF-a)
  • Improved gut barrier function
  • Increased secretion of antibodies in the gut (sIgA)



MicrobiomeX® can be formulated in various dietary supplement forms, including capsules, sachets, tablets, chewable, gummies, shots and shelf-stable drinks.



Additionally, MicrobiomeX® is an ideal partner for symbiotic formulation as it has shown to be highly stable and exerts a synergistic effect in combination with many probiotic strains.



Key applications:



  • Gut health and barrier function support
  • Balance of gut flora (prebiotic)
  • Irritable bowel syndrome (IBS)
  • Synbiotic formulations
  • Sports Nutrition

Functions: Phytochemical

Active Component: Hesperidin, Naringin

Ingredient Origin: Natural Origin, Plant Origin

Labeling Claims: Allergen-free, Halal, Irradiation-free, Kosher, Nanomaterials-free, Naturally Derived, Non-GMO, Plant-Based, TSE-free

Certifications & Compliance: FDA Compliant, FSSC 22000, Halal, Kosher

    Knowde Enhanced TDS

    Identification & Functionality

    Active Component
    Country of Origin
    Pharma & Nutraceuticals Functions
    Ingredients
    Grapefruit Extract, Orange Extract
    Plant Part Used
    Whole fruit

    Features & Benefits

    Food Ingredients Features

    Applications & Uses

    Properties

    Physical Form
    Appearance
    Orange to light brown powder*
    Odor
    Characteristic
    Taste
    Natural origin
    Dispersible in
    Water
    Sparingly soluble in
    Alcohols
    Soluble in
    Diluted alkali
    Typical Properties
    ValueUnitsTest Method / Conditions
    Extraction SolventWater
    Raw Material/Extract Ratio5-10 : 1
    Ratio of Ingredients (Citrus Sinensis: Citrus Paradisi Extract)94 : 6w/w
    Aflatoxins Properties
    ValueUnitsTest Method / Conditions
    Aflatoxin B1max. 2
    Sum of Aflatoxins B1, B2, G1, G2max. 4ppb
    Polycyclic Aromatic Hydrocarbons (PAH)
    ValueUnitsTest Method / Conditions
    Benzo(a)Pyrenemax. 10ppb
    Sum of Benzo(a)Pyrene, Benzo(a)Anthracene, Benzo(B)Fluoranthene and Chrysenemax. 50ppb
    Physico-Chemical Properties
    ValueUnitsTest Method / Conditions
    Loss on Dryingmax. 6
    Ashmax. 5
    Hesperidin (on Anhydrous Basis)min. 80%HPLC (internal method)
    Naringin (on Anhydrous Basis)min. 5%HPLC (internal method)
    Microbiological Values
    ValueUnitsTest Method / Conditions
    Total Plate Countmax. 10^{3}
    Yeast & Moldmax. 10^{2}cfu/g
    Enterobacteriaemax. 10^{2}
    ColiformsAbsence
    Escherichia ColiAbsence
    SalmonellaAbsence
    Nutritional Information
    ValueUnitsTest Method / Conditions
    Nutritional Value (Calculated)228.0kCal/100g
    Total Fat Contentmax. 0.2g/100g
    Saturated Fatty Acids60.0%
    Trans Fatty Acidsmax. 0.1%
    Total Carbohydrates96.5g/100g
    Assimilable Carbohydrates14.1g/100g
    Total Sugar (As Glucose)0.56g/100g
    Total Fibers82.4g/100g
    Total Protein1.6g/100g
    Sodium240.0mg/100g
    Particle Size Distribution
    ValueUnitsTest Method / Conditions
    Particle Size (through 250 μm)90.0%
    Heavy Metals
    ValueUnitsTest Method / Conditions
    Arsenicmax. 0.3
    Cadmiummax. 1ppm
    Mercurymax. 0.1
    Leadmax. 0.5
    Note
    • *Color variations may occur from batch to batch
    • ** Analyzed at raw material level

    Regulatory & Compliance

    Certifications & Compliance

    Storage & Handling

    Shelf Life
    5 years
    Storage & Shelf Life
    • Storage: Keep in tight containers to prevent dust formation. Store in a dry and cool place, away from direct sunlight. Keep away from ignition, heat, or electricity sources
    • Retesting date: 5 years after the date of production (when stored under the described conditions)