Enhanced TDS
Knowde-enriched technical product data sheet
Identification & Functionality
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- Product Families
Features & Benefits
- Benefit Claims (Health)
- Product Features
Its Patented Formula, Based on a Bio-optimized Extract of Turmeric, Considerably Improves Joint Comfort by Acting on 2 Levels:
- On the complaints, by quickly relieving joint discomfort.
- On wear and tear, by slowing down the damage to the cartilage.
- Arantal Is an Effective & Safe Solution
- On acute pain
- On chronic pain: comparable efficacy to NSAIDS without side effects
- Improves patients mobility
- Protects cartilage
- Improves healing of muscle and ligament lesions
- High rate of patients satisfaction
- No severe adverse effects: either gastrointestinal, cardiovascular, renal or hepatic.
Applications & Uses
- Applications
- Dosage Form
Technical Details & Test Data
- Clinical Data
BioXtract in Vitro Studies on Curcumin Show That Curcumin:
- Inhibits pro-inflammatory mediators (PGE2, IL-6, IL-8) and acts on the pain of osteoarthritis.
- Inhibits COX-2 but not COX-1 gene expression, and gives pain relief without unwanted gastrointestinal side effects.
- Inhibits the synthesis of NO and prevents cartilage breakdown in the joint.
- Arantal Is Delivered With a Complete Package of Information, Including Bioxtract Proprietary
- Pre-clinical acute oral toxicity trial in rats showing no particular effect and classifying the product in the danger 5 category DL50 superior 5,000 mg/kg.
- Phase I clinical trial demonstrating bioavailability of ARANTAL's active principals. (Complete report available on request).
- Phase II randomized, double-blind, multicenter clinical trial to evaluate the analgesic efficacy of ARANTAL in patients suffering from gonarthrosis, on a short term period (2 weeks).
- Observational cohort study of ARANTAL on 1,077 patients suffering from osteoarthritis.
- Clinical evaluation of the efficacy of ARANTAL during 6 months on 820 patients suffering from various joint painful osteoarthritis.
- Non-comparative exploratory study evaluating the clinical efficacy of ARANTAL on pain, side effects and effects on some biomarkers of osteoarthritis.
- Observational Study of Gout Attack on 54 patients.
- Safety Evaluation in aged patients with osteoarthritis and comorbidity.
- Observational Study
- Phase II randomized double-blind, multicenter clinical trial to evaluate the analgesic efficacy of ARANTAL in patients suffering from gonarthrosis, on a short term period (2 weeks).
- ARANTAL is an innovative food supplement offering a short-term analgesic effect at the same level than acetaminophen ARANTAL is a safe product dedicated to the relief of pain in osteoarthritis, leading to a relief of pain between 30 to 35% in 2-weeks.
- Observational cohort study of ARANTAL On 1,077 patients suffering from osteoarthritis showing ARANTAL decreased pain with or without a concomitant treatment and that the effect observed depended on the duration of administration ARANTAL additive effect was to decrease the concomitant treatment intake (acetaminophen & NSAID).
- The dosage (2 caps in the morning +2 caps in the afternoon) seemed optimal for most patients, without any relevant side effect reported (only nausea and bloating but infrequent & minor).
- Clinical Evaluation of the Efficacy of Arantal
- Significant reduction on pain (p<0.0001)
- Significant improvement of flexibility (p<0.0001)
- Significant decrease of initial medicamentations (painkillers, NSAIDs, chondroprotectives)
- For 98% of the patients, satisfaction > previous treatment
- Excellent toleration
- Non-comparative Exploratory.study Evaluating the Clinical Efficacy of Arantal
- On pain, side efects and effects on some biomarkers of osteoarthritis showing significant decrease of cartiliage degradation of biomarker Col/2-1 T7% decrease of the inflammatory state of biomarker hsCRP significant improvement of global assessment of disease activity (p<0.005).
- Observational Study of Gout Attack
On 54 Patients Showing:
- Fast improvement in acute pain within 24 to 48 hours for 90% of the patients.
- 65% of the patients continued therapy to prevent attacks with 2 caps/day during 3-6 months.
- 91% were completely satisfied.
- Safety Evaluation in Aged Patients With Osteoarthritis and Comorbidity Showing That Arantal
- Can be used with anticoagulants (no effect reported on coagulation)
- Can be used in case of renal inssuficiency (no effect on urea, on creatinine or on uric acid)
- Presents no interaction with hepatic functions (no action on hepatic parameters like got, gpt, gammagt and alkaline phosphatase)
- Can be used in case of diabetes (no effect on blood glucose nor on glycosylated hemoglobin hba1c).
Packaging & Availability
- Availability
Arantal Is Available Under Several Dosage Forms:
- Gelatin sogtgels
- HPMC hardshell