Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Vitamin Type
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Product Highlights
Vitamin K consists of a group of fat-soluble vitamins that are considered essential to support human health. Known as menaquinone (MK), vitamin K2 is a type of vitamin K found in animal products and fermented foods. Vitamin K2 is a crucial vitamin for supporting heart and bone health. The two major forms of vitamin K2 are MK-4 and MK-7. The number denotes the number of isoprenoid residues in the side chain. MK-4 is naturally synthesized in mammalian cells and is the form that is most studied. MK-7 is naturally produced by fermentation and is discovered to have greater bioavailability. Blue California offers both MK4 and MK7 forms of vitamin K2 for your needs. Blue California's Vitamin K2 is a sustainable source of highly pure source without relying on synthetic production methods.
- Advantages of Blue California’s Vitamin K2
- Sustainably produced using a proprietary fermentation manufacturing process
- Non-GMO and vegan
- Neutral in taste, color, and odor
- Available at 1% active
Applications & Uses
- Markets
- Applications
- Benefit Areas
- Bone Health
- A meta-analysis examining 19 randomized controlled clinical trials (14 examined MK-4, 4 examined MK-7, did not specify form) concluded that Vitamin K2 plays an important role in supporting bone mineral density in postmenopausal women.
- Cardiovascular Health
- A recent prospective cohort study of >50,000 participants who took part in 23 years of follow-up, suggested that a diet rich in vitamin K2 was inversely associated with a risk of hospitalizations related to plaque buildup in arteries.
- Infant Health
- Infants are at risk for vitamin K deficiency. MK-4 is present in human milk, and it has been suggested that its presence may indicate a beneficial role for postnatal development.
- In a human study that examined 31 infants with maternal MK-4 supplementation (15 mg/day) versus 46 infants without, the authors concluded that maternal vitamin K supplementation could help maintain vitamin K levels in newborn infants.
- Bone Health
Properties
- Solubility
Technical Details & Test Data
- Scientific Studies
Bone Health in Healthy Postmenopausal Women
A randomized clinical intervention study was conducted in healthy post-menopausal women to evaluate the effect of vitamin K2 MK-4 supplementation on bone mineral content and bone strength.
- Design :
- 325 healthy non-osteoporotic women aged 55-75 years were randomized to receive either 45 mg/day of vitamin K2 MK-4 or placebo for three years.
- Bone mineral content, hip geometry and bone strength indices were assessed.
- Outcomes :
- MK-4 decreased age-related loss of bone mineral content and increased width of the femoral neck relative to placebo.
- Bone strength of the femoral neck was maintained with MK-4 but decreased with placebo.
Cardiovascular Health
A relationship was determined between vitamin K2 dietary intake and hospitalizations resulting from the buildup of plaque in the lining of arteries.
- Design :
- 53,372 study participants aged 50-65 years enrolled in the Danish Diet, Cancer, and Health Study who had no prior Atherosclerotic Cardiovascular Disease (ASCVD) were studied.
- Vitamin K2 intakes were estimated from dietary data, collected using self-administered semi-quantitative food frequency questionnaires.
- Outcomes :
- Participants with the highest quintile of vitamin K2 intake had a 14% lower risk of hospitalizations related to plaque buildup in arteries compared to those in lowest quintile of intake.
- Further research is needed to determine thresholds of vitamin K2 deficiency and whether supplementation may be a feasible intervention for cardioprotection.
- Design :