Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Ingredient Origin
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- Ingredients
- Clam Extract, Marine Peptide
- Product Families
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Food Ingredients Features
- Product Background
- The Clams (R. philippinarum) belong to the Veneridae clam family and is widely distributed on the coasts of China, Korea, Japan, America, and Spain.
- It is considered a delicacy in Asian countries and utilized as medicine to strengthen organs, lower blood sugar, and promote the blood circulation with a history of usage over 1,000 years.
- We extracted the peptides through our patented Enzytideᵀᴹ technology, which is an eco-friendly and targeted enzymolysis process to break down the protein into small peptide and increase bioactivity.
- Mechanism of Action
- ClamBP™ can help to reduce systolic and diastolic blood pressure, relieve kidney damage by specifically inhibiting the expression of RAS-related pathway factors.
- It regulates concentration of key biomarkers such as ACE\ACE2\Ang-II in blood and kidney tissues thereby protecting overall kidney function and lowering blood pressure.
- Product Highlights
- Clinically proven
- Supports for kidney function
- Helps to stabilize blood pressure
- Established mechanism of action
- Good water solubility and stability
- Kosher and Halal
- Health Benefits
- Hypertension relief
- Helps improve the kidney health with hypertension
- Helps improve the glomerular structure changes, inflammation, and collagen deposition
- Absorption
Full absorption, no significant decrease in ACE inhibition rate in stomach and gut
- Mechanism of Action
- ClamBPᵀᴹ can help to reduce systolic and diastolic blood pressure, relieve kidney damage by specifically inhibiting the expression of RAS-related pathway factors.
- It regulates concentration of key biomarkers such as ACE\ACE2\Ang-II in blood and kidney tissues thereby protecting overall kidney function and lowering blood pressure.
Applications & Uses
- Applications
- Dosage Form
- Food & Nutrition Applications
- Use Level
- Dosage : 500 - 1000 mg
- Dosage and Forms
- ClamBPᵀᴹ can be used in capsule, tablet, beverage, gummy, and more.
- It can also be used as a single ingredient or formulated with other nutrients.
Dosage
Amount per serving % Daily Value ClamBPᵀᴹ 500 mg Food & Beverage : 1 serving
Dietary Supplement : 2 servings
Medical food : 4 servingsTarget Populations
- People with hypertension along with kidney damage
- People with high blood pressure
- People with high blood lipid
- Sub-healthy population with metabolic problems
Properties
- Solubility
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Peptides Content | 72.0 | % | — |
| Molecular Weight | max. 1000 | Dalton | — |
Regulatory & Compliance
- Certifications & Compliance
- Regulatory Status
Food Ingredient in Asia, Europe, North America, GRAS (in the process).
Technical Details & Test Data
- Clinical Studies on
We have run an open-label human clinical study with 30 adults aged between 18-65 years old and with mild to moderate blood hypertension.
The subjects received the 1,800 mg/day ClamBPᵀᴹ for 6 weeks.
Figure 1 : Significant reduction in blood pressure within 6 weeks. No adverse events were observed during the study and no changes were found in the hematological analysis.
- Clinical Studies on
Fig 2 : Reduced the concentration of ACE activity in the kidney and increase the
concentration of ACE2 in SHRs- Clinical Studies on
Fig 3 : Regulate the blood lipid by reducing the concentration of serum total cholesterol (TC), Triglyceride (TG), Low-density lipoprotein (LDL) and increasing the concentration of high-density lipoprotein (HDL).
- Efficacy in Hypertension
Systolic pressure reduced from 144 mmHg at the start of the trial to 135 mm Hg after 6 weeks, diastolic pressure from 88 mm Hg to 82 mmHg.
Safety & Health
- Safety
It was more than 3,330 mg/kg in NOAEL rats, is equivalent to a clinical dosage of 200 g.