Knowde Enhanced TDS
Identification & Functionality
- Chemical Name
- Pharma & Nutraceuticals Functions
- CAS No.
- 9003-39-8
- EC No.
- 618-363-4
- Technologies
- Chemical Structure
Features & Benefits
- Features
Physical Properties :
Non-ionic polymer
High porosity and hydration
Easy compression and viscoelastic deformation
No gel formation
Stable in acids and basesPerformance Impact :
No interaction with ionic APIs (i.e. Ranitidine, Cetirizine)
Combines wicking and swelling mechanisms to achieve rapid tablet disintegration at low concentrations(1-5%)
Increased tablet tensile strength and reduced friability due to high compressibility. Especially suitable for poorly compressible APIs
No gel formation even at higher concentrations (10%), idea for ODTs
Suitable for a variety of pH sensitive formulations- Summary
The case study demonstrates the effectiveness of PolyStardone® as a super disintegrant for a tablet matrix containing both water-soluble (lactose) and insoluble (dibasic calcium phosphate), mediumcompactable fillers. The performance of PolyStardone® was compared to other crospovidone products in the market. We believe that: PolyStardone® XL and PolyStardone® XL-10 have similar performance to import competitor A and import B, and are better than domestic competitor C and D in terms of compactibility and disintegration capabilities. In this case, PolyStardone® XL ensures rapid disintegration regardless of compaction force. Furthermore, PolyStardone® XL-10 offers additional benefits in increasing tablet tensile strength without a compromise in its disintegration efficiency.
Applications & Uses
- Markets
- Dosage Form
- Application
Insoluble in water or common organic solvents, the powder particles are porous microstructures with high specific surface area.
As a super disintegretant, it will not form gel and can effectively improve the disintegration time.
Properties
- Appearance
- White or yellowish-white powder
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Name | Crospovidone (PVPP) | — | — |
| Peroxides | max. 100 | ppm | — |
| Molecular formula | (C6H9NO)n | — | — |
| NVP | max. 10 | ppm | — |
| CDE register number | F20180000229 | — | — |
| Sulfated ash | max. 0.1 | % | — |
| Water-solube substances | max. 1.5 | % | — |
| Typical D50 | 100-120 | μm | — |
| Loss on drying | max. 5.0 | % | — |
| Nitrogen | 11.0-12.8 | % | — |
| Typical peroxide | max. 100 | ppm | — |
Regulatory & Compliance
- Certifications & Compliance
- Grade
Technical Details & Test Data
- Technical Analysis
Packaging & Availability
- Packaging and Storage
Packed in 20 kg fiber drum or 15 kg plastic drum, inner lined with PE bags
Special packing is available according to customer's requirement
Preserve in tight containers