Knowde Enhanced TDS
Identification & Functionality
- Chemical Name
- Pharma & Nutraceuticals Functions
- CAS No.
- 9003-39-8
- EC No.
- 618-363-4
- Technologies
Features & Benefits
- Product Properties
- Excellent solubility
- water and a range of organic solvents
- Low viscosity solution
- High binding efficiency
- Forming complex with APIs
- Non-ionic polymer
- Summary
In this case, Stardone® K30 has similar performance to that of import competitor A and B, and is better than domestic competitor C and D in terms of tablet compressibility, tensile strength, friability, and disintegration time.
Applications & Uses
- Markets
- Dosage Form
- Performance Impact
- Fast dispersibility in solvents (including water). Aqueous solution are preferred to solvent-based systems but may not be suitable for drugs which are degraded hydrolysis. Hence solubility in a range of organic solvents is favorable.
- Ease of handing→high viscosity binder solution may cause clogging of spray nozzle
- Lower use levels required to produce tablets with higher breaking force and lower friability at potentially lower compaction force
- No effect on drug dissolution, can improve the drug dispersion and water solubility
- no contraindication risk of compatibility with ionic pharmaceutical ingredients
Properties
Regulatory & Compliance
- Certifications & Compliance
- Grade
Technical Details & Test Data
- Technical Analysis
- Formulation Result of Naproxen
- Case Study
Naproxen, whose bioavailability is rate-limited due to its poor solubility was chosen as a model API. It is typically wet granulated because of its poor compactibility. In many cases, the addition of other binder-fillers before tableting is necessary in order to achieve suitable tablet hardness with low friability. In this case study, wet granulation of Naproxen was performed with 5% of Povidone K30 as a binder solution.
Stardone®K30 against other similar products on the market was compared.
Packaging & Availability