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CutiBiome CLR is a synergistic complex of lipophilic extracts from Manuka, Black Pepper and Magnolia. It provides essential support for the natural balance between skin and its microbiota in difficult situations, like acne and dandruff. CutiBiome CLR reduces the film forming activity and significantly inhibits the growth of virulent phylotypes of Cutibacterium acnes. It strongly reduces inflammation involved in acne and dandruff. Sebum, comedones, pustules and pimples are reduced dramatically, as was confirmed by instrumental determinations and the volunteers themselves. Other in vivo studies showed potent reduction of dandruff. 4 weeks of 3 times weekly use of a hair tonic with CutiBiome CLR lead to similar results to Piroctone Olamine, but clearly outperformed it in reducing scalp oiliness, sensitivity and itch.