BioVXR® Acid-Resistant HPMC Capsules

Identification & Functionality

Chemical Name

Hydroxypropyl Methylcellulose

Pharma & Nutraceuticals Functions

Capsule

CAS No.

9004-65-3

EC No.

618-389-6

Technologies

Pharmaceuticals & Nutraceuticals

Product Families

Pharmaceuticals & Nutraceuticals — Excipients

Modified & Controlled Release

Capsule Design

Features & Benefits

Labeling Claims

Allergen-free,

Clean Label,

Halal,

Kosher,

Non-GMO,

Preservative-free,

Vegan,

Vegetarian

Products Charactristics

Protect your acid sensitive ingredients from gastric acid and delayed release in intestinal tracts

• Well-suited for Probiotic, Enzyme, acid-sensitive ingredients
• With advantages of HPMC capsules - low moisture, making it also  suitable for hygroscopic formulations
• Without chemical solvents to meets Clean Label’s need.
• Allergen Free, Preservative Free, Non-GMO

Advantage

• Protect nutrients from gastric acid
  BioVXR® acid-resistant capsules protect acid-vulnerable ingredients from gastric acid and release in intestinal tract. 
• Well-suited for acid-sensitive ingredients, such as Probiotic and Enzyme dosages
  Characteristics of acid resistance & delayed release in intestinal tract are great for acid-vulnerable ingredients, such as probiotics, enzymes, collagen, ginkgo, grape seed .and so on. In addition, BioVXR® has advantages of HPMC capsules - low moisture, making it well-suited for hygroscopic formulations.
• No additional coating or banding process
  Without using chemical solvents can reduce destruction of ingredients during production.
  Shorten the new product development process and verification, new product can be launched to market in shorter period of time.

• Made of natural ingredient - HPMC
  BioVXR® acid-resistant capsules are made of HPMC(Hydroxypropyl Methylcellulose), which is derived from the pine tree cellulose. HPMC is approved as “Generally Recognized as Safe” (GRAS) by the US FDA. BioVXR®, certified by Vegetarian Society, Halal & Kosher, complies with our customers who have a cultural or vegetarian needs.

 

Applications & Uses

Markets

Food & Nutrition,

Healthcare & Pharma

Applications

Food & Nutrition — Nutrition & Well Being

Nutraceuticals & Supplements,

Other Nutrition Applications

Healthcare & Pharma — Pharmaceutical Manufacturing

API Manufacturing

Regulatory & Compliance

Certifications & Compliance

Halal,

Kosher

Certification

• US DMF No.: 030931
• Patents protected in the U.S and Taiwan
• Kosher, Halal and Vegetarian Society certified

Technical Details & Test Data

Specification

Size	Length (mm)				Thickness (mm)		External diameter(mm)		Weight (mg)
	Cap	Body	Pre-Locked	Locked	Cap	Body	Cap	Body
#00	11.73	20.20	25.80	23.30	0.110	0.110	8.53	8.24	118±7.0
#0	11.18	18.40	23.75	21.30	0.105	0.105	7.66	7.37	95±7.0
#1	10.01	16.50	21.23	1920	0. 100	0.100	6.96	6.65	74±50
Tolerance	±0.38	±0.38	±0.85	±0.50	±0.020	±0.020	±0.06	±0.06

BioVXR® Dissolution

Indicator for observation
• After 120 minutes of the pH1.2 environment, the dissolution rate must be lower than 10%.
• After 45 minutes of the pH6.8 environment, the dissolution rate must be higher than 80%.

Gelatin Capsules
After 30 minutes of the pH1.2 environment, gelatin capsules are nearly dissolved which have no protection for ingredient.
HPMC Capsules
After 120 minutes of the pH1.2 environment, the dissolution rate is 55.8% which half of the ingredient has been released.
BioVXR® acid resistant HPMC capsules
After 120 minutes of the pH1.2 environment, the dissolution rate is lower than 10%, which has protection for the ingredient.
After 45 minutes of the pH6.8 environment, the dissolution rate reached 89.18%, which most of the absorption occurred in
intestinal tract.
Other delayed release capsules
After 120 minutes of the pH1.2 environment, the dissolution rate is higher than 10%, which has weak protection for the ingredient.
After 45 minutes of the pH6.8 environment, the dissolution rate reached 32.19%, which less than half of the ingredient has been
released