Anti-Plaque Toothpaste

Formulation

Name	Ingredient	Supplier	%
Phase A
Deionized Water		—	23.59
Viscarin GP 209 Chondrus crispus Extract	Chondrus crispus Extract	—	1.00
Deionized Water		—	5.00
Sodium Saccharin Sodium Saccharin	Sodium Saccharin	—	0.25
Sodium Monofluorophosphate Sodium Monofluorophosphate	Sodium Monofluorophosphate	—	0.76
Sorbitol (Sol. 70%) Sorbitol	Sorbitol	—	25.00
PEG-8 PEG-8	PEG-8	—	4.00
Phase C
Sorbitol (Sol. 70%) Sorbitol	Sorbitol	—	2.00
A310 Tudor Aspen Titanium Dioxide	Titanium Dioxide	—	0.50
Phase B
Tetrasodium Pyrophosphate Tetrasodium Pyrophosphate	Tetrasodium Pyrophosphate	—	1.75
Tetrapotassium Pyrophosphate Tetrapotassium Pyrophosphate	Tetrapotassium Pyrophosphate	—	1.75
Tixosil 73 Hydrated Silica	Hydrated Silica	—	7.00
Tixosil 43 Hydrated Silica	Hydrated Silica	—	7.00
Aerosil 200 Silica	Silica	—	1.00
Sodium Bicarbonate Sodium Bicarbonate	Sodium Bicarbonate	—	12.00
Phase E
Aroma Aroma	Aroma	—	1.20
Irgasan DP 300 Triclosan	Triclosan	—	0.20
Phase D
Demin. Water		—	4.00
Andean QD Ultra Powder Quillaja saponaria Extract	Quillaja saponaria Extract	—	2.00

Preliminary phases:

Phase C: Mix the ingredients until homogeneous suspension.
Phase D: Mix the ingredients until clear solution under cupboard; excessive foam formation must be avoided.
Phase E: Mix the ingredients until clear solution.

Addition scheme:

In main mixer, add Viscarin PC 209 to water and homogenize with turbine and blades, under vacuum, for 10', then heat the phase to 65°C, always under vacuum. At this temperature, homogenize with turbine and blades under vacuum for 10'. Sample and check homogeneity.
In a side mixer add ingredients A1, mixing until clear solution after each addition.
Add phase A1 to phase A and homogenize with turbine and blades for 10’ while starting to cool to room temperature.
Add, in sequence, ingredients B and homogenize with turbine and blades for 10’ after each addition. Check homogeneity of the phase after each addition.
Add, in sequence, phases C, D and E while mixing with blades under vacuum for 5’ after each addition. Take a sample for analytical controls.