Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Ingredient Name
- Pharma & Nutraceuticals Functions
- Ingredients
- Blue Skullcap Extract
- Product Families
- Biological Constituents
It is a rich source of constituents with known biological activity:
- Flavonoids (baicalin, baicalein, wogonoside, wogonin)
- Diterpenoids (scutelaterin A, B, and C)
- Phenylpropanoids (caffeic acid, cinnamic acid, coumaric acid, ferulic acid)
- Essential oils (terpenoids)
- Amino acids and melatonin
Features & Benefits
- Benefit Claims (Health)
- Product Highlights
Quality:
- Supply chain entirely made in Italy, from the field to the final extract.
- Official analytical method (EP)
Efficiency:
- In vitro studies.
- Antioxidant Activity
BlueCALM™ has strong antioxidant activity showing a significant dose-dependent radical scavenger activity in different experimental models.
Scavenger activity of BlueCALM™ towards the ABTS radical.
Each value represents the mean of ± EMS (n=6).
***p<0.001 indicates a statistically significant reduction in ABTS radical levels compared to the control (Ctrl).- Anti Glycation Activity
BlueCALM™ has shown anti-glycation activity: It inhibits the formation of AGEs (Advanced glycation end products), some harmful substances deriving from the combination of proteins and fats with sugars, that are involved in many chronic degenerative diseases, including Alzheimer’s, and in aging. These results may support the plant’s neuro protective effects, already reported by available scientific data.
- BlueCALM™ improves mild anxiety and insomnia.
BlueCALM™ has been tested on a human adrenocortical carcinoma cell line, an in vitro model commonly used to investigate the mechanism of action of molecules with anti-anxiety activity. BlueCALM™ significatively inhibits the release of cortisol, the body’s main “stress hormone”.
Inhibitory activity of BlueCALM™ in cells previously treated with forskolin (F), a cAMP activator that induces steroidogenesis.
Properties
- Typical Properties
- Compounds Contained
HPLC-DAD chromatogram of the phenolic compounds contained in BlueCALMTM (Scutellaria lateriflora L.) Dry extract. 1. Gallic acid 1; 2. Gallic acid 2; 3. Catechin; 4. Chlorogenic acid; 5. Epicatechin; 6. Caffeic acid; 7. Siringic acid; 8. Coumaric acid; 9. Ferulic acid; 10. Rutin; 11. Benzoic acid; 12. Cinnamic acid; 13. Naringenin; 14. Baicalein
| Value | Units | Test Method / Conditions | |
| Dry Powder Extract (Baicalin) | 10 | % | — |
Regulatory & Compliance
- Certifications & Compliance
- Certifications
- Botanical species certified by DNA barcoding to prevent the adulteration with hepatotoxic Teucrium species.
- Compliance with EU legislation on Food and Food Supplements.