Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Ingredient Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Pharma & Nutraceuticals Functions
- Ingredients
- Cistus Extract, Blue Skullcap Extract
- Product Families
Features & Benefits
- Benefit Claims
- Benefit Claims (Health)
- Labeling Claims
- Food Ingredients Features
- Product Highlights
The oral cavity forms an indispensable part of the human microbiome, for its unique and diverse microflora distributed within the periodontal crevice and pockets, tongue dorsum and other mucosal surfaces. Some of these bacteria are implicated in the pathogenesis of oral diseases such as caries and periodontitis. Porphyromonas gingivalis is a main etiological factor in periodontal diseases.
The oral microflora includes up to approximately 1000 species of bacteria, fungi, viruses, archaea and protozoa that live in the human oral cavity. The oral microflora, in a healthy host, under normal conditions, maintains balanced symbiotic relationships, which have been defined as a ‘‘microbial homeostasis” or ‘‘eubiosis”. Despite the resiliency, insults or changes can shift the eubiotic balance to an unbalanced parasitic/pathogenic state, known as ‘‘dysbiosis” in the host.
- Product Highlight
Dental caries and dental plaque are among the most common diseases worldwide and are caused by a mixture of microorganisms and food debris. Specific types of acid-producing bacteria, especially Streptococcus mutans, are the main cause of caries. The presence of Scutellaria lateriflora L. extract in PLANoràl contributes to the antibacteria activity of the blend against this pathogen (the bacterial grow inhibition accounts for ~70% compared to ampicillin).
- Efficiency of Planoràl
The efficacy of PLANoràl® is also proved by the induction of beta-defensins release with and without the presence of inflammation. ßβ-Defensins are primarily expressed by epithelial cells at mucosal surfaces and have a broad spectrum of antimicrobial activity, being effective against Gram-positive and Gram-negative bacteria, fungi, and enveloped viruses. In addition to their antimicrobial action, defensins are involved in a variety of cellular functions, including stimulation of immune system by cell chemotaxis, cytokines secretion and histamine release.
Applications & Uses
- Applications
- Food & Nutrition Applications
- Physiologic and Healthcare Applications
- Eubiosis of the oral cavity.
- Antioxidant.
Properties
- Odor
- Characteristic
- Taste
- Characteristic
- Partially Soluble in
- Water
- Typical Properties
- Microbiological Values
- Nutritional Information
- Heavy Metals
| Value | Units | Test Method / Conditions | |
| Particle Size (through 300 microns) | 90 | % | — |
| Bulk Density | 500 - 800 | g/L | — |
| Loss on Drying | max. 7.0 | %w/w | — |
| pH | 4 - 6 | — | — |
| Heavy Metals | max. 20 | ppm | (method C Ph. Eur. current edition) |
| Aflatoxin B1 | max. 2 | ppb | — |
| Aflatoxin B1,B2,G1,G2 | max. 4 | ppb | — |
| Benzo(a)pyrene | max. 10 | ppb | — |
| Sum of Benzo(a)pyrene, benzo(a)anthracene, benzo(b)fluoranthene and chrysene | max. 50 | ppb | — |
| Pyrrolizidine Alkaloids | max. 400 | ppb | — |
| Bile-tolerant gram-negative bacteria | max. 100 | ufc/g | — |
| Value | Units | Test Method / Conditions | |
| Bacterial Count | max. 50000 | ufc/g | (TAMC: ref. 5.1.8, cat. B oral use): |
| Yeasts and Moulds Count | max. 500 | ufc/g | (TYMC: ref. 5.1.8, cat. B oral use): |
| Value | Units | Test Method / Conditions | |
| Carbohydrates | 90 - 95 | % | — |
| Fat Content | 0 - 1 | % | — |
| Protein Content | 0 | % | — |
| Energy Value | 405 | Kcal/100 gr | — |
| Value | Units | Test Method / Conditions | |
| Minerals | 5 - 7 | % | — |
| Lead Content | max. 3 | ppm | (ref. Reg. (EC) 1881/2006) |
| Cadmium Content | max. 1 | ppm | (ref. Reg. (EC) 1881/2006) |
| Mercury Content | max. 0.1 | ppm | (ref. Reg. (EC) 1881/2006) |
Regulatory & Compliance
- Certifications & Compliance
- Certifications
- DNA CERTIFIED RAW MATERIAL.
- GMO: Free from GMO (Reg. (EC) 1829/2003 and 1830/2003) BSE/TSE FREE - GLUTEN FREE.
- ALLERGENS: Free from substances or products causing allergies or intolerances (Reg. (EU) 1169/2011 Annex II).
Technical Details & Test Data
- Bacterial Growth Rate
a vs c → p<0.01
b vs c → p<0.01Scutellaria lateriflora L. and Cistus x incanus L. work synergically in a unique blend (patent N. IT 102021000018035) acting as antibacterial against Porphyromonas gingivalis to prevent periodontitis.
Storage & Handling
- Shelf Life
- 2 Years
- Storage
Store in a well closed container away from moisture and direct sun light.