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PhytoChol® Inject: parenteral grade cholesterol for nucleic acid therapeutics
Cholesterol is an important functional excipient for parenteral mRNA-based drug delivery systems. As part of the lipid nanoparticle protecting the mRNA, it can modulate drug release, enhance the ability of the drug formulation to penetrate cell membranes, and provide a stabilization effect.
PhytoChol® Inject is Evonik’s high-purity, vegetal- derived cholesterol suitable for parenteral applications. This ultra-low endotoxin cholesterol provides a first-rate alternative to traditional animal- based cholesterol, and is USP-NF, Ph.Eur and JP compliant.
Lipid nanoparticle:
PhytoChol® BioPharma to optimize your cell culture:
Supplementing a cell culture medium with cholesterol can improve cell culture outcomes or even be essential for some cell lines. Chemically defined cell culture media that are free from fetal bovine serum (FBS) and natural lipids often require the addition of cholesterol to help improve cell growth, protein production, virus production and infectivity of produced viruses.
Evonik’s PhytoChol® BioPharma is a highly pure, non-animal-derived cholesterol with proven use in cell culture media or supplement formulations. PhytoChol® BioPharma can be used in a wide range of cell lines including NS0 cell culture for protein production, culture of insect cell lines and culture of packaging cell lines for virus production. In addition to offering a highly pure and consistent product, Evonik can also provide application and formulation guidelines.