Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Ingredient Name
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- Ingredients
- Turmeric
Features & Benefits
- Benefit Claims (Health)
- Food Ingredients Features
- Product Highlights
The rhizome of Curcuma longa contains many active compounds of which the following are the most important:
- curcuminoïds such as curcumine, demethoxycurcumin, bisdemethoxycurcumin, cyclocurcumin, calebin A
- essential oil with turmerones, furanodiene, and sesquiterpenes such as bisabolanes, germacrone and β-elemene
- turmerines (antioxidant peptides)
- alkaloids, tannins, saponins, sterols, flavonoids
Product Info- Proven enhanced bioavailability of curcumin
- Conversion of curcuminoids to their bioactive tetrahydrocurcuminoids
- Increase in phenolic compounds and related antioxidant capacity
- Paraprobiotic effect
- Much lower daily dose needed
- Health Benefits
- Very strong anti-inflammatory and powerful antioxidant
- Hepatoprotection, prevention of oxidative stressinduced liver injuries
- Memory preservation, especially at older age since oxidative stress-induced deterioration of brain function and brain cell destruction are counteracted
- Supporting immune function through JNK signaling pathways promoting white blood cell survival May help in the prevention of influenza and other viral infections
- May help relieve acute inflammation and pain (osteoarthritis, rheumatoid arthritis, inflammatory bowel diseases)
- May help in low-grade inflammation (in the case of atherosclerosis, diabetes, depression) May help athletes recovering from exercise-induce muscle damage
- Chemoprevention
- Why Fermenting Turmeric?
Turmeric rhizome is the only recognized dietary source of curcuminoïds, which are extraordinary herbal constituents with well-established anti-inflammatory properties. Unfortunately, curcuminoids (75-80% curcumin) are poorly absorbed and rapidly metabolized for excretion from the body. Therefore, the focus is mainly on enhancing curcumin bioavailability but also on conversion of the original curcuminoids to the more active and more stable tetrahydrocurcuminoid forms through our proprietary lactic acid fermentation.
Enhanced curcumin bioavailability by fermentation - proven with the gold standard for intestinal absorption!
- Curcumin from Fermeric™ (fermented turmeric powder) is much more bioavailable than curcumin from turmeric powder (unfermented) when subjected to the in vitro MDCK gold standard for intestinal absorption.
- When MDCK cells (canine kidney epithelial cells) are cultured on semiporous filters they form confluent monolayers that model the intestinal barrier.
- Apparent permeability (P app) through MDCK monolayers is widely considered to be an in vitro gold standard for assessing the uptake efficiency of substances into the body, and hereby predicting in vivo absorption.
- Beneath graphs show permeability efficiencies for both fermented (Fermeric™) and unfermented turmeric. The indicated apparent permeability coefficients (P app) are representing the appearance rate of curcumin in the receiver compartment of the test set-up, after transport across the MDCK cells − after 24 and 48 hours.
Source: NB Research Center and Tri Neo Biotechnology
- Much more curcumin from Fermeric™ or fermented turmeric powder than from unfermented turmeric powder is transported across the MDCK cell monolayer (a representative of the intestinal barrier):
- 17,2 times more at 24 hours
- 6,3 times more at 48 hours
- Curcuminoids are transformed into tetrahydrocurcumoids by fermentation : A specific probiotic strain in the fermentation process is able to convert turmeric’s curcuminoids (yellow pigments) into their tetrahydrocurcuminoid metabolites (colorless THCs). THCs have higher stability, higher bioavailability and higher antioxidant potency than the parent curcuminoids. They are often considered the ultimate bioactive metabolites inside the body after oral turmeric consumption.
- Enrichment in phenolic compounds by fermentation : During fermentation of turmeric powder our specific probiotic strain largely increases the level of phenolic compounds, which coincides with an enhanced antioxidant activity. The increased antioxidant potential was illustrated both in vitro and in vivo. Moreover, the phenolic antioxidant compounds were very well absorbed.
- Paraprobiotic Effect : When fermentation is complete, our specific probiotic strain is inactivated. This increases shelf life of fermented turmeric powder, since there is no need for maintaining the cold chain to preserve viability.Current evidence shows that the non-viable form of our specific probiotic strain maintains health-promoting effects such as immune-modulation and fortification of intestinal barrier integrity, because of key structures in its cell wall and secreted metabolites amongst other things. This is called the paraprobiotic effect.
- Much lower daily dose needed : The combined effect of fermentation and natural turmeric matrix preservation leads to enhanced curcumin bioavailability, enrichment in stable and easily absorbable THCs and a more powerful antioxidative strength. Therefore, a daily dose of 300 - 500 mg is a logical choice under normal circumstances.
Applications & Uses
- Markets
- Use Level
- 300 - 500
Properties
- Active Ingredient
| Value | Units | Test Method / Conditions | |
| Curcuminoids | min. 2.3 | % | - |
| Curcumin | min. 1.4 | % | - |
| Paraprobiotic | min. 20 billion | cfu/g | - |
Technical Details & Test Data
- Science
Many studies show the therapeutic properties of turmeric. Curcumin is one of the most extensively studied herbal constituents. It is therefore scientifically very well founded. However, it is important that the curcuminoids are available in their stable and easily absorbable form, because this is a prerequisite for the therapeutic power of this promising plant.