Knowde Enhanced TDS
Identification & Functionality
- Chemical Name
- Pharma & Nutraceuticals Functions
- CAS No.
- 9000-11-7
- EC No.
- 618-326-2
- Technologies
Features & Benefits
- Product Highlights
- Chemically stable
The chemical structure of CMEC is built up by ethel linkage, difficult to be hydrolyzed with CMEC itself being chemically stable.
- Disintegration of pH dependency
The disintegration behavior of tablets coated with CMEC depends on the pH regardless of the buffer solution. It is slower to disintegrate in a lower pH but faster in a higher pH. By taking advantage of this property, using enteric material is possible. Also, the combination with controlled release materials of pH independency enables the formulation of various dissolution profiles.
- As a Matrix-Forming Material
CMEC is used for a matrix-forming material with API. The release speed rate is controllable by adjusting the ratio of API and CMEC.
- Improve dissolution of poorly soluble drugs
CMEC is a carrier of solid dispersion for improving solubility of poorly soluble API.
- Protective coating for sugar-coated tablet
The CMEC film thickness of 100μm has suitable moisture prevention. It is effective to use CMEC as protective coating agent on sugar-coated tablets including water-sensitive API.
Applications & Uses
- Markets
- Dosage Form
- Manufacturing Technology
- Usage Guidelines
Add CMEC to water : ethanol = 1 : 0.5 solution to disperse. Then add remaining ethanol and agitate to dissolve until smooth.
Properties
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Weighted mean molecular (Mw) | 4.9×10-4 | — | — |
| Number average molecular weight (Mn) | 1.4×10-4 | — | — |
| Variance ratio (Mw/Mn) | 3.5 | — | — |
Regulatory & Compliance
- Certifications & Compliance
- Grade
Technical Details & Test Data
- Solubility Profile
CMEC is insoluble in water, but soluble in water and ethanol (ethanol 70-90%) combined.