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HPS-101 complies with *JPE (Japanese Pharmaceutical Excipients) standards under Hydroxypropyl Starch. It is a hydroxypropyl ether derivative of Corn Starch(JP). HPS-101 is used as filler, disintegrator and dispersant.

Chemical Name: Hydroxypropyl Starch

CAS Number: 9049-76-7

Functions: Disintegrant, Dispersant, Filler

Dosage Form: Tablets

Certifications & Compliance: Japan Pharmacopeia (JP)

Synonyms: 2-Hydroxypropyl starch, 2-Hydroxypropyl starch ether, Hydroxypropylated starch, Propoxylated starch, Starch hydroxypropyl ether

Technical Data Sheet
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Knowde Enhanced TDS

Identification & Functionality

Pharma & Nutraceuticals Functions
CAS No.
9049-76-7
EC No.
618-565-2

Features & Benefits

Product Highlights

Excellent disintegration

The following figures show the tablet hardness and disintegration time for the tablets compressed at 4 force levels (6, 8, 10, 12kN) with the recipe of adding 5% of HPS-101 to Lactose-G. Adding HPS-101 shortens disintegration time without lowering tablet hardness.

HPS 101 - Product Highlights

  • API Stability

Less interaction with API as it is an ether derivative of starch.

  • HPS-101 is gelatinized quicker and retrogrades* slower than starch.

Starch retrogradation means starch becoming insoluble in water as an opposite process of gelatinization. Lactose-G HPS-101 5% add 0 4 8 12 16 20 6kN 8kN 10kN 12kN Compression force Disintegration time(min) 50 70 90 110 130 6kN 8kN 10kN 12kN Compression force Hardness (N) - 2 -

  • Stabilizing suspension effectively

HPS-101 for liquid formulation maintains the suspension liquid condition for a long period by suppressing the precipitation of aqueous-insoluble materials.

Applications & Uses

Dosage Form

Regulatory & Compliance

Certifications & Compliance