Knowde Enhanced TDS
Identification & Functionality
- Pharma & Nutraceuticals Functions
- Technologies
Features & Benefits
- Product Highlights
- Superior in disintegration
When added to 100M Lactose The below graph shows the hardness of tablets and disintegration time when adding 0-30% of PERFILLER®-101 to 100M Lactose and setting the compression force at 7.5, 10, 12.5kN. By adding PERFILLER®-101, the hardness is increased and the disintegration time was shortened by 1 minute, while over 9 minutes was needed without PERFILLER®-101.
- Excellence in compression formulation
PERFILLER®-101 is effective when it is added to powders (eg; ascorbic acid, mannitol) that are hard to form.
- Better miscibility higher effectiveness as API dispersion media
Mixing example with acetaminophen
Stable uniformity dispersed powder can be obtained after 3 minutes mixing time under the below conditions by adding 1% of acetaminophen(AAP) and PERFILLER®-101.
Mixing machine : Kotobuki Mixwell V-10 type mixing machine(Tokuju Corporation) Volume, added amount : 22L, 4kg(AAP : PERFILLER®-101 or 200M Lactose = 1:99) Rotating speed : 36 rpm
- Improvement in fluidity
Example with dried cork tree bark extract Adding PERFILLER®-101 to low fluidity dried cork tree bark extract improves fluidity. This feature facilitates the formulation for powdered medicine and direct compression.
Dried extract of cork tree bark 100% 90% 80% PERFILLER®-101 0% 10% 20% Fluidity index 46.0 51.0 57.5
Applications & Uses
- Markets
- Dosage Form
Properties
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Mean Diameter | 47.2 | μm | — |
| Synthetic Aluminum Silicate Content | approx. 20 | % | — |
| Hydroxypropyl Starch Content | approx. 60 | % | — |
| Crystalline Cellulose Content | approx. 20 | % | — |
Regulatory & Compliance
- Certifications & Compliance
- Grade
Technical Details & Test Data
- SEM Image
The fluidity index is the total index of the repose angle, degree of compassion, spatula angle, homogeneity degree or agglomeration degree. The greater the fluidity intex, the better the fluidity.
