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Galen N Galanthamine HBR

It is an alkaloid obtained from hydro alcohol extraction of daffodil (Narcissus).
Technical Data Sheet
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Identification & Functionality

Features & Benefits

Benefit Claims (Health)
Food Ingredients Features

Applications & Uses

Applications

Medical car-freatment of mild to moderate Aizheimers disease and various other memory impairments, in particular those of vascular origin. Galanthamine belongs to class of medications called acetylcholinesterase inhibitors. It works by increasing the amount of a certain natural substances in the brain needed for memory and thought. Galanthamine may improve the ability to think and remember or slow the loss of these abilities in people who have AD. Cholinesterase inhibitors inhibit (block) the action of acetylcholinesterase, the enzyme responsible for the destruction of acetyicholine. By blocking the enzyme that destroys acetylcholine, Galanthamine increases the concentrafion of acetylcholine in the brain, and this increase is belleved to be responsible for the improvement in thinking.

Properties

Physical Form
Appearance
Fine crystaline powder
ldentitication
Color reaction
Soluble in
Water
Insoluble in
ether, In 95% ethanol and chloroform
Typical Properties
ValueUnitsTest Method / Conditions
Acidity or AlkalinityAccording to the specification
Assay of Galanthamine98.0 - 102.0
Chloroform60ppm
Ethanol5000ppm
Heavy Metais Content20ppm
Impurity E (N-desmethylaalanthamine)0.6%
Loss on drying1
Related Substance (by HPLC Impurity A (Narvedine))0.15%
Residual sovents Acetone5000ppm
Specific Optical Rotation (25% in water)-90.00 to -100.0
Sulphate Ash0.1%
Total Impurity0.8%
Unspecified Impurity0.1%
Microbiological Values
ValueUnitsTest Method / Conditions
Bacteria104CFU/g
E. coli, Salmonellanot alowed
Enterobacteriaceae102
Mold and barm102CFU/g

Regulatory & Compliance

Packaging & Availability

Packaging Type