Knowde Enhanced TDS
Identification & Functionality
- Chemical Family
- Country of Origin
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Background
- The Oral microbiome: The first microorganism to colonize and to protect our mouth is Streptococcus salivarius. This bacteria protects us in endless ways for the rest of our entire life. As soon as the teeth appear S mutans and S sanguis colonizes the hard surface. Finally, approximately 700 species, inhabit the mouth at a neutral pH. All together they maintain our health. The S salivarius controls and restores the balance where necessary
- Tooth decay: As long as this immense community is balanced, the teeth and our general health is guaranteed. Unhealthy habits such as the consumption of glucose, alcohol and soda disrupt this balance. S mutans transforms glucose into plaque and acids. The plaque is an ideal habitat for acid producing bacteria. These acids then destroy the enamel of teeth and bring the oral microbiome out of balance. The oral microbiome loses its protective power: the unprotected teeth decay
- General health: The mouth is the gate of our body. Inhaled air and consumed food are potential dangers containing pathogens. A healthy and balanced oral microbiota is an efficient gate keeper for our teeth, gums and our entire body. Chronical diseases and high blood pressure are associated with an unbalanced oral microbiome. S salivarius protects us, through the inhibition of acid-producing, mal odor and other unwanted microbes. The production of ammonia, neutralizing the destructive acids and by making the oral cavity resistant to the colonization of unwanted microbes S salivarius is the manager and guardian of the oral microbiome balance
- Product Properties
- Supports the protection of teeth
- Supports the gums
- Reduce the negative effect of sugar, soda and alcohol
- Prevents tooth decay
- Reduce bad breath
- Natural sweetener
- Strengthening sensitive teeth
- Fighting against dental plaque
- Improving the anti-microbial protection
- Neutralizing the adverse effect of an unhealthy diet
- Improving the performance of toothpaste
- PreBIULIN® ORAL also promotes indirectly the overall health of the human body
Applications & Uses
- Markets
- Applications
- Application Format
- Oral Care Applications
- Use Level
- 1.5 - 5% (in mouth washes), 1.5 - 5% (in tooth paste)
- Mechanism of Action
preBIULIN® ORAL maintains the oral hygiene by strengthening and protecting the oral microbiome balance under all circumstances. PreBIULIN® ORAL supports directly the protective and regulating S salivarius, while inhibiting the growth of microorganisms responsible for tooth decay (caries), sensitive gums and bad breath. A healthy oral microbiome stands for excellent oral health, which results not only in attractive teeth but also in a healthy body. preBIULIN® ORAL improves the growth of the protective S salivarius (In-vitro). The growth rate of incubated S salivarius is followed during 8h. Compared to other prebiotics, preBIULIN® ORAL supports by far the most efficient S salivarius. preBIULIN® ORAL works both through mouthwash and toothpaste.
- Product Application
- Toothpastes: Solid toothpaste & Desensitizing toothpaste
- Mount washes
Properties
- Physical Form
- Appearance
- Thick liquid (at 20°C)
- Odor
- Typical slight odor
- Soluble in
- Water, Propylene glycol, Glycerine, Ethanol (70%)
- Insoluble in
- Mineral oil, Oil, Dimethicone, Cyclomethicone, Soya oil, Octylstearate
- Compatible with
- Silicone oils, Vegetable oils, Mineral oil, Preservatives, Vitamins, Parfum, Electrolytes AI/Zr +++, Electrolytes ++, Electrolytes +, DHA, Carbomer, Colorants - oil soluble, Colorants - water soluble, Essential oils, Plant extracts, Synthetic oils
- Physico-Chemical Properties
- Microbiological Values
- Composition
- Impurities
- Heavy Metals
- Formulation Guideline
Name Compatibility Peroxides Incompatible Oxidizing agents Incompatible Hydrogen peroxide Incompatible Reducing agents Incompatible Thioglycolates Incompatible - Maximum heating temperature: < 60°C - During 8 hours
- Incorporation: Product has to be added to the water phase
| Value | Units | Test Method / Conditions | |
| pH (10% Solution, at 20°C) | 5 - 7 | — | — |
| Refractive Index (at 20°C) | 1.4805 - 1.4875 | — | — |
| pH | 4.3 - 10.0 | — | — |
| Value | Units | Test Method / Conditions | |
| Total Vival Count (TVC) | max. 100 | cfu/g | — |
| Yeast | max. 10 | cfu/g | — |
| Molds | max. 10 | cfu/g | — |
| Gram Negative Bacteria | Absent | per g | — |
| Candida albicans | Absent | per g | — |
| Enterobacteriaceae | Absent | per g | — |
| Escherichia coli | Absent | per g | — |
| Pseudomonas aeruginosa | Absent | per g | — |
| Staphyloccocus aureus | Absent | per g | — |
| Value | Units | Test Method / Conditions | |
| Fructooligosaccharides | 55 - 65 | % | — |
| Glycerin | 22 - 28 | % | — |
| Aqua | 15 - 20 | % | — |
| Inulin | 0.5 - 5 | % | — |
| Value | Units | Test Method / Conditions | |
| Diethylene Glycol (CMR Impurity) | Below detectable levels | — | — |
| Value | Units | Test Method / Conditions | |
| Total | max. 10 | ppm | — |
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
- Quality of the Product
Type Details Natural Index (acc. to ISO 16128) NI=0.25 Natural Origin Index (acc. to ISO 16128) NOI=1 Organic Index (acc. to ISO 16128) Ol=0 COSMOS Product certified NaTrue Product certified
Technical Details & Test Data
- Production Process Information
Mixture of:
- Fructooligosaccharides produced by enzymatic reaction of sugar from sugar cane (Saccharum officinarum)/ Sugar beet (Beta vulgaris). Enzyme used for the production of FTasa. Country of origin: Spain
- Inulin extracted from chicory roots (Cichorium Intybus) - country of origin: Belgium / Sun roots. Country of origin Poland
- Glycerol, food/pharma grade obtained from plant oils (sunflower, rapeseed) rich in triglycerides (esters of glycerol with long-chain carboxylic acids) by the hydrolysis of these triglycerides. The product is purified by treatment with activated carbon to remove organic impurities, alkali to remove unreacted glycerol esters, and ion exchange to remove salts. High purity glycerol (> 99.5%) is obtained by multi-step distillation. Country of origin: EU
- Study results of preBIULIN® ORAL in mouthwash (In-vivo)
Protects S salivarius after alcohol consumption. Rinsing the mouth with 10% ethanol (blanco) is compared to rinsing with 10% ethanol + 3.3% preBIULIN® ORAL.
Reduction of alcohol-damage on the oral microbiome
Reduction of sugar-damage on the oral microbiome: The mouth is rinsed with glucose. Rinsing afterwards with a mouthwash (Blanco) is compared to a mouthwash enriched with 3.3% preBIULIN® ORAL.
Reduction of cariogenic bacteria after sugar consumption
Reduction of soda-damage of on the oral microbiome: The mouth is rinsed with soda (pH 2.7 / 12% glucose). Rinsing afterwards with a mouthwash (Blanco) is compared to a mouthwash enriched with 3.3% preBIULIN® ORAL.
Suppresion of cariogenic bacteria after soda consumption
- Study results of preBIULIN ORAL in toothpaste (In-vivo)
Brushing the teeth with a commercial toothpaste containing SLS (Blanco) is compared to the toothpaste enriched with 3.3% preBIULIN ORAL. Improved support of S salivarius.
Suppression of cariogenic bacteria
Reduced growth of bad breath bacteria
Reduced growth of unwanted bacteria
Safety & Health
- Impurities
- Pesticides: Not expected to be present
- CMR impurities: Impurity from Glycerin is absent, according to Ph/USP requirements
- Polyacrylic Aromatic Hydrocarbons: Not expected to be present
- Prohibited impurities: Not expected to be present
- Other impurities: Not expected to be present
- Residual solvent: Not expected to be present
- Residual monomers: Not expected to be present
- Residual reactants: Not expected to be present
Packaging & Availability
- Packaging Type
- Packages Information
Quantity (kg) Type Package material Amount EURO Pallet Amount Block Pallet
1 kg Bucket PP NR NR 5 kg Bucket PP NR NR - Packages Information
Quantity (kg) Type Package material Amount EURO Pallet Amount Block Pallet
1 kg Bucket PP NR NR 5 kg Bucket PP NR NR
Storage & Handling
- Shelf Life
- 12 Months
- Storage Information
Store in a dry, cool and well-ventilated area below 35°C. Keep in original, tightly sealed containers, away from heat and direct sunlight.