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Hydrogel with Cerasome

Formulation

Hydrogel with Cerasome

NameIngredientSupplier%
Phase A
Cerasome 9005
Water (and) Alcohol (and) Cholesterol (and) Hydrogenated Lecithin (and) Ceramide III (and) Ceramide II (and) Palmitic Acid (and) Oleic Acid
Water (and) Alcohol (and) Cholesterol (and) Hydrogenated Lecithin (and) Ceramide III (and) Ceramide II (and) Palmitic Acid (and) Oleic Acid15.00 g
Glycerol
Glycerin
Glycerin25.00 g
Germall II
Diazolidinyl Urea
Diazolidinyl Urea30.30 g
EDTA-Na2
Disodium EDTA
Disodium EDTA20.10 g
Euxyl K 400
Methyldibromo Glutaronitrile (and) Phenoxyethanol
Methyldibromo Glutaronitrile (and) Phenoxyethanol40.05 g
Rose water
Rose water
Rose water4.00 g
Dist. Water
Water
Water24.24 g
Phase C
Tris(hydroxymethyl)- aminomethan
Tromethamin
Tromethamin20.81 g
Dist. Water
Water
Water10.00 g
Phase B
Carbopol ETD 2020
Acrylates/C10-C30 Alkyl Acrylate Crosspolymer
Acrylates/C10-C30 Alkyl Acrylate Crosspolymer50.50 g
Dist. Water
Water
Water50.00 g

Preparation: Procedure 1) All components of phase A are mixed together to give a homogeneous solution. 2) All components of phase B are mixed at RT then heated up to 50 – 60 °C and stirred to give a homogeneous solution. 3) Add phase C to phase B. 4) Add phase A to gel of phase B and C and stir thoroughly.

Notes: Suppliers (1) Lipoid GmbH (2) Merck (3) Sutton Laboratories Inc. (4) Schülke & Mayr GmbH (5) BF Goodrich Company