Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Cosmetic Ingredients Functions
- CAS No.
- 223749-07-3
- Technologies
- Product Families
- Chemical Structure
- Origin
- Aqua - Mineral
- Propylene Glycol - Vegetable
- Ziziphus Joazeiro Bark Extract - Vegetable
Features & Benefits
- Benefit Claims
- Labeling Claims
- Action
- Rapidly eliminates dandruff, with a 72-hour action
- Calms and soothes: anti-itching effect
- Regulates sebum secretion
- Restores the skin barrier and normalizes cell renewal
- Cosmetic Benefits
The scalp immediately regains a healthy appearance, scales disappear, along with itching and irritations.
Applications & Uses
- Hair Care Applications
- Treatment Product Applications
- Cosmetic Use
- Anti-dandruff care products
- Hair products for sensitive scalps
- Hair products for greasy hair
- Formulations
- Concentration for use: 1 to 2%
- use pH: 4.0 to 10.0
- Caution for use: Add at the end of the preparation process (water-soluble).
Properties
- Physical Form
Regulatory & Compliance
- Certifications & Compliance
- REACH Status
INCI Concentration REACH Status Aqua 46.75 - 48.25 % Water
exempted annex IVPropylene Glycol 46.75 - 48.25 % Propylene Glycol
registered n°01-2119456809-23Ziziphus Joazeiro Bark Extract 3.5 - 6.5 % Exempt: < 1 ton/year (dry matter)
Technical Details & Test Data
- Mechanism of Action
With its very high saponin content, DANDRILYS® rapidly eliminates dandruff and reduces irritation and itching reactions.
DANDRILYS® is more effective than zinc pyrithione (reference chemical active substance) and acts more rapidly.- Scientific Process
- Dandruff
Dandruff is caused by abnormal desquamation of the scalp's epidermal cells. This phenomenon is promoted by multiple factors: stress, hormonal imbalance, excessive sweating and repeated scalp aggressions. The proliferation of Malassezia fungi enhances the phenomenon, causing inflammation (string itching, irritations, excess sebum).
- DANDRILYS®
A saponin-rich natural active substance, this is a complete and ultra-effective anti-dandruff agent that rapidly eliminates dandruff, lasting 72 hours and which possesses an anti-itching soothing action. Indeed, it reduces the release of the inflammation mediator that causes itching: histamine.
- Proven Efficacy - In Vivo Test
ANTI-DANDRUFF ACTION
Method: scoring
Half-head shampoo treatment:
23 volunteers with 1% DANDRILYS® or placebo
+ 11 volunteers with 1% Zinc pyrithione or 1% DANDRILYS®A FASTER EFFECT than Zinc pyrithione, and lasting for 72h: -40% dandruff after 6 days
> DANDRILYS® significantly eliminates dandruff versus placebo (ratio>1) (p<0.04)
A MORE POWERFUL EFFECT than Zinc pyrithione: DANDRILYS® is 33% more effective after 6 days
- Anti-Itching Action - In Vitro Test
Histamine release: -27% (2% DANDRILYS®)
- Sebum Regulation - In ViVo Test
- DANDRILYS regulates sebum secretion both during and after treatment
- Conversely, Zinc pyrithione significantly increases sebum secretion
SELF-EVALUATION
DANDRILYS® is significantly better appreciated than Zinc pyrithione.
A gentle and soothing active substance, it is recommended for use as a regular shampoo (contrary to conventional anti-dandruff products). When used daily, it rapidly eliminates dandruff.
Anti-inflammatory & anti-itching properties
Reduced histamine release
Safety & Health
- Toxicological Tests
Tests Method Tested Concentration Results Skin Irritation Patch Test 5 % Not irritant Eye Irritation Het cam 5 % Moderatly
irritantPhototoxicity 3T3 cells Product tested at 8
dilutionsNot
phototoxicSensitization Marzulli-Maibach 10 % Very
good compatibilityMutagenicity test 10 % Not mutagenic
Storage & Handling
- Storage
Keep in a dark place, in the original packaging, at an ambient temperature between 15 and 25 °C. Use rapidly once opened, or transfer to sterile packaging.