Knowde Enhanced TDS
Identification & Functionality
- Carrier
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 223749-07-3
- Technologies
- Product Families
- Origin
- Aqua - Mineral
- Propanediol - Vegetable
- Ziziphus Joazeiro Bark Extract - Vegetable
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Background
Dandruff is a scalp disorder affecting up to 50% of world population (Piérard-Franchiment et al., 2006) and tending to affect men more than women. Dandruff causes itchy and flaking skin with mild inflammation (it is a mild form of seborrheic dermatitis) (Schartz et al., 2013). Beside discomfort and bad aspect of scalp, dandruff also has social and psychological impact, affecting self-esteem and confidence (Manuel and Ranganathan, 2001).
Current solutions include Zinc Pyrithione, featuring a strong efficacy but also unpleasant
side effects: skin irritation, dryness or allergies, leading to recurrent regulatory reviews.
Greentech designed a natural active ingredient to cleanse scalp and efficiently eliminate
dandruff, redness and sebum, with a care effect on scalp microbiota. For a healthy scalp.- Action
- Rebalances scalp bacteriobiota & mycobiota
- Rapidly eliminates dandruff, with a 72-hour action
- Complete long-lasting action: anti-dandruff, anti-itching & sebum control
- Promotes a healthier scalp
Applications & Uses
- Application Format
- Hair Care Applications
- Treatment Product Applications
- Cosmetic Use
- Anti-dandruff daily shampoo & hair conditioner
- Oil control hair care
- Sensitive scalp hair products
- Purifying hair products
- Scalp health booster
- Scalp microbiota modulating products
- Formulations
- Concentration for use: 1-2%
- pH for use: 4-10
- Caution for use: Add in formulations at 35-40 °C, while cooling or at any time in cold preparation.
Properties
- Physical Form
- Odor
- Characteristic
- Appearance
- Liquid
- Soluble in
- Water, Propanediol, 10% in water
- Typical Properties
- Physico-Chemical Properties
- Quantifications
- Microbiological Values
| Value | Units | Test Method / Conditions | |
| Natural Content | 51.75 | % | - |
| Plant Rate Implementation Extraction | 20 | % | - |
| Natural Origin Content | 100 | % | - |
| Value | Units | Test Method / Conditions | |
| Dry Matter | 3.5 - 6.5 | % | GT006 |
| Refraction Index | 1.370 - 1.410 | - | GT007 |
| Specific Gravity | 1.010 - 1.080 | - | GT008 |
| pH Value (Direct) | 5.2 - 7.2 | - | GT005 |
| Value | Units | Test Method / Conditions | |
| Saponins (exp: jujuboside A) | min. 10.0 | %/MS - %/DM | GT0102 |
| Value | Units | Test Method / Conditions | |
| Detection of Candida albicans | Absence | - | NF EN ISO 18416 |
| Detection of Enterobacteria | Absence | - | ISO 18415 |
| Detection of Escherichia coli | Absence | - | NF EN ISO 21150 |
| Detection of Pseudomonas aeruginosa | Absence | - | NF EN ISO 22717 |
| Detection of Staphylococcus aureus | Absence | - | NF EN ISO 22718 |
| Enumeration of Mesophilic Aerobic Bacteria | max. 100 | ufc/mL - cfu/mL | ISO 21149 |
| Enumeration of Yeasts and Molds | max. 100 | ufc/mL - cfu/mL | ISO 16212 |
Regulatory & Compliance
- Certifications & Compliance
- REACH Status
INCI Concentration REACH Status Aqua 46.75 - 48.25 % Water exempted annex IV Propanediol 46.75 - 48.25 % Propanediol registered
n°01-2119489383-28Ziziphus Joazeiro Bark Extract 3.5 - 6.5 % Exempt: annex V point 8
Technical Details & Test Data
- Greentech Innovation
- Natural & Safe Alternative To Zinc Pyrithione
- Microbiota-Powered Anti-Dandruff For A Healthier Scalp: Rebalances Bacteriobiota + Mycobiota
- Long-Lasting Action, Anti-Dandruff, Anti-Itching & Sebum Control
A SYSTEMIC APPROACH OF DANDRUFF (SCALP PHYSIOLOGY + MICROBIOTA)
Dandruff (also known as Pityriasis capitis) is characterized by itchy and flaky scalp with mild inflammatory reaction. It is a mild form of seborrheic dermatitis (Schwartz et al., 2013).
As summarized in the figure below, there are several extrinsic factors (like lack of hygiene, excessive use of hair sprays/gels/wax…) and intrinsic factors (like scalp microbiota dysbiosis, individual susceptibility, hormonal imbalances…) that seem to play a role in dandruff formation.
More precisely, this inflammatory chronic disorder is related to scalp skin barrier disruption, epidermal cellular proliferation and differentiation, as well as shifts in gene expression patterns, and in cytokine and lipid production (Bonnist et al., 2014).
Predisposing factors & interactions in the pathogenesis of dandruff. (adapted from Borda et al., 2015)
- Immunity
- Epidermal Barrier
- Genetics
- Neurogenic Factor
- Emotional Stress
- Nutrition
- Other
The scalp has a biotic network out of which Staphylococcus spp., Propionibacterium spp. and Malassezia spp are known components (the two first being part of bacteria and thus bacteriobiota, the later being part of yeast and thus mycobiota).
Dandruff has been closely associated to a scalp microbiota dysbiosis, with a disbalance in the proportion of these major fungal and bacterial population colonizing the scalp (Park et al., 2012). More precisely, the central dandruff hypothesis remains that the lipophilic yeast Malassezia, previously known as Pityrosporum, is the main causative agent of dandruff. Indeed, on the dandruff-afflicted scalp, the level of Malassezia increases to almost double the normal level. It has been found that some metabolic products of tryptophan produced by Malassezia, for example, indole derivatives, are the main cause of dandruff.
Aware of these mechanisms causing dandruff, GREENTECH R&D has developed a natural solution based on specific saponins (jujubosides) from Joazeiro bark to efficiently and quickly treat dandruff and rebalance scalp microbiota for a long-lasting effect.- Proven Efficacy - Clinical Study 1 - In Vivo Test
Clinical Study Design
- 22 male subjects (40-65 yo) with all hair & scalp types (dry-greasy-normal):
- 12 with adherent dandruff score ≥2.5 and total dandruff score ≥4.
Shampoo: DANDRILYS 1% vs Placebo - 10 with healthy scalp (control group).
No treatment
Evaluation Parameters
- Scalp microbiota (high throughput DNA sequencing; bacteria: 16S ribosomal RNA; fungi: ITS1 ribosomal DNA)
- Total dandruff + Erythema/Irritation (for both grading; 0-5)
- DANDRILYS® REBALANCES SCALP BACTERIOBIOTA & MYCOBIOTA
DANDRILYS® rebalances the BACTERIOBIOTA & MYCOBIOTA of scalp with dandruff towards a healthy scalp microbiota- DANDRILYS® DECREASES BOTH DANDRUFF & ITCHING
ANTI-DANDRUFF ANTI-ITCHING -59%**** AFTER 2 WASHES (D3) -54%* -86%**** AFTER 4 WASHES (D9) -83%** *p<0.05; **p<0.01; ****p<0.0001 vs D0 . Significant differences also vs placebo
Illustrative pictures after 5 washes (12 days) Double blind test on 23 subjects with middle to high level of dandruff (after washout). Shampoo with DANDRILYS® 1% vs placebo.
For Clinical Study 2 - In Vivo Test
Please refer this link:
Safety & Health
- Toxicological Tests
Tests Method Tested Concentration Results Skin Irritation Patch Test 5 % Not irritant Eye Irritation Het cam 5 % Moderatly
irritantPhototoxicity 3T3 cells Product tested at 8 dilutions Not
phototoxicSensitization HRIPT 10 % Very good skin compatibility Mutagenicity Test Ame test 10 % Not mutagenic
Storage & Handling
- Shelf Life
- 24 months
- Storage
15 / +25°C
Keep in the original packaging, without opening, in the recommended storage conditions.
Advice before use : Agitation