Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- EINECS No.
- 200-578-6, 231-791-2, 204-589-7, 215-185-5, 200-405-4, 200-289-5, 232-307-2
- Technologies
- Product Families
- Origin
- Aspidosperma quebracho
Features & Benefits
- Benefit Claims
- Labeling Claims
- Action
- Anti-free radicals
- DNA protector
- Prevents skin damage
- Delays the effects of aging
- Cosmetic Benefits
- The skin is protected from environmental aggressions and from damages caused by UV radiation, it recovers its regenerative capabilities.
- NUCLEOLYS limits signs of photo-aging and preserves the skin youthful appearance.
Applications & Uses
- Markets
- Applications
- Skin Care Applications
- Sun Care Applications
- Cosmetic Use
- Protective care products
- Anti-wrinkle and anti-aging care products
- Sun care and after-sun products
- Regenerative care products
- Formulations
Concentration for use: 2.5 to 5%
Precautions for use: Shake before use to bring to ambient temperature. Add at the end of the preparation process, at a temperature of less than 40 °C. Formulation pH between 4 and 6.5. Formula compatible with liposome stability.
Properties
- Physical Form
- Appearance
- Viscous liquid
- Odor
- Characteristic
- Soluble in
- Water, Glycerin, Denatured alcohol, 1% in water
- Partially Soluble in
- 1% in ethanol
- Physico-Chemical Properties
- Quantifications
- Microbiological Values
| Value | Units | Test Method / Conditions | |
| Dry Matter | 10.0 - 18.0 | % | GT006 |
| pH Value (Direct) | 4.5 - 6.5 | — | GT005 |
| Value | Units | Test Method / Conditions | |
| Gallic Acid | 0.01 - 0.02 | — | GT256 |
| Proanthocyanidine Oligomers | 1.98 - 1.99 | % | GT054 |
| Viscosity (velocity 10, spindle 6, 1min) | 10 000 - 30 000 | mPa.s | GT037 |
| Value | Units | Test Method / Conditions | |
| Detection of Candida albicans | Absence | — | ISO 18416 |
| Detection of Enterobacteria | Absence | — | ISO 18415 |
| Detection of Escherichia coli | Absence | — | NF EN ISO 21150 |
| Detection of Pseudomonas aeruginosa | Absence | — | NF EN ISO 22717 |
| Detection of Staphylococcus aureus | Absence | — | ISO 22718 |
| Enumeration of Mesophilic Aerobic Bacteria | max. 100 | ufc/g - cfu/g | ISO 21149 |
| Enumeration of Yeasts and Molds | max. 100 | ufc/g - cfu/g | ISO 16212 |
Regulatory & Compliance
- Certifications & Compliance
- REACH Status
INCI Concentration REACH Status Aqua 76.3 % Water exempted annex IV Glycerin 8 % Glycerin exempted: annexe V point 9 Alcohol 7 % Ethanol registered n°01-2119457610-
43Lecithin 5 % Lecithin exempted: annex IV Aspergillus/Aspidosperma
Quebracho Ferment2 % Exempt: < 1 ton/year (dry matter) Phenoxyethanol 0.8 % Phenoxyethanol
registered n° 01-2119488943-21Acrylates/c10-30 Alkyl Acrylate
Crosspolymer0.5 % Exempted Sodium Hydroxide 0.3 % Sodium Hydroxide
registered n°01-2119457892-27Tocopheryl Acetate 0.1 % Tocopheryl Acetate
registered n°01-2119457641-38
Technical Details & Test Data
- Mechanism of Action
NUCLEOLYS is a unique active ingredient. It protects the DNA of the skin cells from free radicals and UV aggressions. NUCLEOLYS also restores DNA self-repair capabilities.
- Scientific Process
- Free radicals
Free radicals are responsible for tissue damages: they destroy membrane proteins and lipids, they attack DNA and degrade hyaluronic acid, a fundamental component of the dermis. Their formation, and hence skin cell aging, is promoted by many environmental factors. Free radicals scavengers help prevent this deterioration.
- Condensed tannins
Proanthocyanidols are flavonic polymers; they form complexes with collagen fibers, thus protecting the underlying layers. They trap free radicals, thus inhibiting lipid peroxidation.
NUCLEOLYS is a unique plant-derived active substance, perfectly stabilized by micro-encapsulation. It protects cellular DNA, possesses anti-elastase and antioxidant activities and restores the ability of DNA to self-repair.- Proven Efficacy - In Vitro Test
FREE RADICAL INHIBITION
DNA PROTECTION (DNA PLASMIDS)
RESTORATION OF DNA REPAIR SYSTEM
DNA PROTECTION - CELL CULTURE
Storage & Handling
- Shelf Life
- 12 months
- Storage
15 / +25°C
Keep in the original packaging, without opening, in the recommended storage conditions.