Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Pharma & Nutraceuticals Functions
- Ingredients
- Collagen
- Product Families
Features & Benefits
- Benefit Claims
- Benefit Claims (Health)
- Labeling Claims
- Food Ingredients Features
- Benefits
- SCP-II® offers benefits for joint and skin health at a very low dose.
- SCP-II® is the only ingredient that contains both Undenatured Proteoglycan (>40%) and Undenatured Type II Collagen (>40%).
- SCP-II® is produced from salmon nasal cartilage in Hokkaido, Japan using a patented extraction method.
- SCP-II® has no heavy metals and is produced in a GMP facilities.
- Research
Human studies suggest that Undenatured Type II Collagen and Proteoglycan may*:
- Improves joint health.
- Helps with minor joint discomforts.
- Supports joint mobility.
- Supports cartilage and joint function.
- Reduces the appearance of wrinkles.
- Improves skin condition including, moisturizing, and hydrating the skin.
Applications & Uses
- Applications
- Food & Nutrition Applications
- Skin Care Applications
- Treatment Product Applications
- Applications
- Foods
- Beverages
- Capsules
- Tablets
- Cosmetics
Properties
- Odor
- Scentless/slight peculiar smell
- Microbiological Values
- Nutritional Information
- Specifications
- Heavy Metals
| Value | Units | Test Method / Conditions | |
| Coliforms | Negative cfu/g | — | Desoxycholate Agar Medium |
| Total Plate Count | max. 3,000 | cfu/g | Standard Agar Medium Method |
| Yeasts and Molds Count | max. 100 | cfu/g | Chloramphenicol Addition Potato Dextrose Agar Medium Method |
| Value | Units | Test Method / Conditions | |
| Ash Content | 15.4 | g/100g | — |
| Carbohydrates | 17 | g/100g | — |
| Energy | 331 | Kcal/100g | — |
| Fat | 0.7 | g/100g | — |
| Moisture | 2.7 | g/100g | — |
| Protein Content | 64.2 | g/100g | — |
| Salt Equivalent (Calculated from Sodium Content) | 1.56 | g/100g | — |
| Sodium | 631 | mg/100g | — |
| Value | Units | Test Method / Conditions | |
| pH Value | 7.0 - 8.0 | — | pH Meter |
| Ash Content | max. 25 | % | Ignition residue test method |
| Loss on Drying | max. 10 | % | Dry weight loss test method |
| Molecular Weight | 900 - 1400 | kDalton | HPLC Gel Filtration |
| Undenatured Proteoglycan | min. 40 | % | HPLC Gel Filtration |
| Undenatured Type || Collagen | min. 40 | % | Automatic amino acid analysis Polyacrylamide gel electrophoresis |
| Value | Units | Test Method / Conditions | |
| Arsenic Content | max. 2 | ppm | ICP-MS Method |
| Cadmium Content | max. 0.3 | ppm | ICP-MS Method |
| Lead Content | max. 2 | ppm | ICP-MS Method |
| Mercury Content | max. 0.5 | ppm | ICP-MS Method |
Regulatory & Compliance
Technical Details & Test Data
- Clinical Studies on Undenatured Type II Collagen and Proteoglycan
SCP-II® Complex (2019) Specifications:
Min. 40% Natural Undenatured Salmon Type II Collagen
Min. 40% Natural Undenatured Salmon ProteoglycanEfficacy Study Results Test Item Dose in Study Equivalent SCP-II (2019) Dose
SCP-II helps with minor joint
discomforts in healthy individuals.
(Kuriyama et.al. 2016)SCP-II (2016):
40% type II Collagen
+ 30% Proteoglycan50mg SCP-II (2016) =
20mg Type II Collagen
15mg Proteoglycan50mg SCP-II (2021) =
20mg Type II Collagen
20mg ProteoglycanSalmon Proteoglycan helps with
minor joint discomforts in healthy
individuals, and also improved joint
mobility and discomfort in healthy
individuals 50 years or older.
(Kuriyama et al. 2021)Proteoglycan 10mg Proteoglycan 25mg SCP-II =
10mg Proteoglycan
10mg Type II CollagenSalmon Proteoglycan improved
joint discomfort in healthy
individuals. (Najima et al. 2016)Proteoglycan 10mg Proteoglycan 25mg SCP-II =
10mg Proteoglycan
10mg Type II CollagenSalmon Proteoglycan improved
minor joint discomfort. (Kuriyama
et al., 2017)Proteoglycan 5mg Proteoglycan 12.5mg SCP-II =
5mg Proteoglycan
5mg Type II CollagenSalmon Proteoglycan Improved skin
condition including moisturizing
and hydrating the skin and reducing
the appearance of wrinkles.
(Takahashi et al. 2015)Proteoglycan 10mg Proteoglycan 25mg SCP-II =
10mg Proteoglycan
10mg Type II CollagenSalmon Proteoglycan helps with
cartilage and normal joint function.
(Tomonaga et al. 2017)Proteoglycan 5mg Proteoglycan 12.5mg SCP-II =
5mg Proteoglycan
5mg Type II CollagenUndenatured Type II Collagen
from chicken cartilage improves
joint health. (Lugo et. Al. 2016)Type II Collagen 40mg UC-II = 10mg Type II Collagen 25mg SCP-II =
10mg Type II Collagen
10mg ProteoglycanAn effective dose of SCP-II® can range as little as 14mg to 50mg per day.
- SCP-II® Mechanism of Action
The mechanism of action for SCP-II® is believed to be found on the active site of undenatured Type II Collagen, which is an epitope, and the active site of undenatured Proteoglycan, which is its terminal C-site. These active sites are recognized by the body when ingested, and induce immune tolerance by signaling the body to stop releasing inflammatory cytokines and chemokines in the joints.
Denatured Type II Collagen and denatured Proteoglycan will not have this same effect because the active sites will not be intact in the denatured form.
The intestine is responsible for about 80% of immune function.
The function of undenatured Type II Collagen in the intestine
The intestine is responsible for about 80% of immune function.
The function of Proteoglycan (PG) in the intestine.
Safety & Health
- Safety
Oral 28-day repeated dose toxicity study in rats.
Storage & Handling
- Shelf Life
- 2 years
- Storage and Shelf Life
Room Temperature, away from exposure to sunlight and moisture
Shelf Life: 2 years from manufacturing date