Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Animal Feed & Nutrition Functions
- Ingredients
- Saccharomyces Cerevisiae
- Technologies
Features & Benefits
- Labeling Claims
- Animal Feed & Nutrition Features
- Product Overview
Unique Activation:
Patented yeast hydrolysate. Its specific acid hydrolysis process without separating the extract results in high amount of soluble, bioactive yeast structures that are available for the microbes and immune system in the gut.
Dual Function:
High content of soluble, molecular structures makes Progut® especially effective in modulating microbiota and immunity. Progut® has outstanding E. coli and Salmonella binding capacity and it beneficially modulates intestinal and rumen microbiota. This is combined with the ability to speed up the immune maturation of young animals helping them to cope better with challenges.
Performance Booster:
Progut® has proven to bring consistent customer benefits. Improved feed efficiency and growth, reduced diarrhea risk, faster immune protection against challenges and improved milk production have been shown both in scientific and commercial trials.
- Progut® for Poultry
Improves broiler performance:
- Progut® improved feed conversion ratio and reduced mortality in young broilers until 14 days of age.
- Progut® improved broiler feed conversion ratio during 42 days rearing period on average by 2 points.
Benefits wellbeing of birds by modulating immunity:
- Progut® increased concentration of IgA in broiler gut by 38%.
- Progut® increased secretion of interferon-γ in Eimeria challenged broilers by 68–82%, but not in unchallenged birds.
- Progut® improved day old chicken immunity when applied to broiler breeder feed.
- Progut® alleviated the consequences of chronic enteritis in layers.
Binds salmonella and E. Coli:
- Progut® reduced Salmonella count in boot swab by almost one log in comparison to control, when applied in broiler diet during the last 2 weeks of rearing.
- Progut® outperformed competing yeast products tested in in vitro binding capacity of poultry related Salmonella and E. coli strains.
Practical Applications:
Broilers and Turkeys:
- Starter period: 0.9 kg/t of feed
- Grower period: 0.6 kg/t of feed
- Finisher period: 0.35 kg/t of feed
Layers and Breeder stock:
- Layers, Pre-lay and Phase 1: 0.9 kg/t of feed
- Breeder stock: 0.9 kg/t of feed
The recommended doses can be increased to double in challenging conditions.
- Progut® for Pigs
We call Progut® a 3-in 1 product, for thanks to its unique hydrolysis Progut® has a profound immune stimulation ability, it can bind with pathogens like E. coli and balance gut microbiota.
At weaning, immature immune and intestinal system can affect the growth and feed efficiency of the piglets. Many stress factors associated with the weaning period, such as removing from the sow, changes in the diet, adapting to a new environment, mixing of piglets from different farms also lead to an intestinal dysfunction in piglets can be associated with proliferation of enterotoxigenic E. coli and post-weaning diarrhea. Progut® has a proven record of performance improvement in wean piglets by reducing the risk of diarrhea, improve feed intake and FCR. Due to the hydrolysis process Progut® contains relatively higher amount of sugar structures which provide an alternative binding sites to bacteria and reduces the attachment of E. coli to gut mucus. However, Progut® is fastening the immunomaturation of young animals by increasing the amount of immune cells in the intestinal epithelium and by increasing immunoglobulin production.Prevents of E-Coli Problems:
- Reduced fecal shedding of hemolytic E. coli in challenged piglets
- Higher in vitro binding capacity of pig related E. coli strains than the tested competing yeast products
- Higher prevention of E. coli attachment to piglet ileal mucus than the tested competing yeast products
- Reduced intestinal permeability increase under E. coli challenge ex vivo
Prevents Weaning Diarrhea in Piglets:
- Reduced risk of weaning diarrhea in E. coli challenged piglets
- Reduced diarrhea in E. coli challenged piglets
Modulates Immunity:
- Increased antibody titers against the sheep red blood cells in weaners, and tendency to increase IgG in serum 2 weeks post-weaning
- Increased concentration of IgA and amount of CD4 and CD8 + lymphocytes in the gut
- Increased production of IP-10 cytokine (chemo-attractant) in dendritic cell model in vitro (Bioplex immunoassay)
Improves Piglet Performance:
- Improved FCR in weaners
- Improved growth and FCR in weaners
Improves sow and litter performance:
- Progut® in sow feed before farrowing increased colostrum yield and fat, reduced farrowing duration, and numerically reduced pre-weaning mortality
- Progut® in sow feed before farrowing numerically increased IgG in colostrum, piglet birth and weaning weights, improved litter uniformity, and reduced pre-weaning mortality
Practical Applications:
PIGLETS: Training of immunity, prevention of weaning diarrhea problems and improvement of performance of weaned piglets.
- Suckling piglets: 1.8 kg/ton
- Piglets from weaning to 2 weeks post-weaning 1.2 kg/ton
- Older piglets (2 weeks post-weaning >): 0.6 kg/ton
SOWS: Improvement of litter performance through improved colostrum yield and quality. Minimum one week before farrowing until end of lactation 1.0 kg/ton.
The recommended doses can be increased to double in challenging conditions.- Progut® for Young Ruminants
Progut® has shown performance benefits in applications for calves, goat kids and lambs. Along with the beneficial effects in the gut Progut® enhances rumen development and function.
Trains the immunity to respond better to challenges:
- Progut® enhanced response to bacterial and viral challenges, measured by increased amounts of bacterial and viral specific IgA in the serum of calves challenged with Hog cholera and Erysipelothrix insidiossa.
Effectively binds calf specific e. Coli and salmonella:
- Progut® showed an outstanding capacity to bind calf specific E. coli and Salmonella bacteria in comparison to competing yeast cell wall products.
Reduces diarrhea risk:
- Progut® addition in starter feed improved fecal and health scores of young calves.
Improves growth and feed efficiency:
- Progut® addition in starter feed improved growth and FCR of young calves.
Practical Application:
In calves, lambs and goat kids for training of immunity, prevention of diarrhea problems and improvement of performance
- Starter feeds: 0.6–1.8 kg/ton of feed
- Milk replacers: 1.8 kg/ton of feed
- Progut® for Aquaculture
Modulation of immunity:
- Increased production of IP-10 cytokine (chemo-attractant) in dendritic cell model in vitro (Bioplex immunoassay) (Glykos research FIN 2015)
- Tendency (P=0.068) to higher concentration of superoxide dismutase in Asian seabass (Kasetsart University, Thailand 2020)
Improved condition of intestinal epithelium:
- Increased villus height in two trials in Asian seabass (Kasetsart University, Thailand 2020)
Improved performance of fish and shrimp:
- Improved feed intake, growth and feed conversion ratio of Asian seabass (Kasetsart University, Thailand 2020)
- Improved performance of shrimp (Field trials in the Philippines)
Practical Applications:
In fish and shrimp: 0.5–1.5 kg/ton
- Production Features
- Production process grants a stable content of the bio-active compounds
- Strict internal and external quality control
Applications & Uses
- Markets
- Applications
Regulatory & Compliance
- Certifications & Compliance
- Certifications & Registrations
- GMP+ (Nastola) and ISO certified
- A feed material status in European Union, registered in several countries beyond EU
Technical Details & Test Data
- Technical Details
Progut® trains the immunity for challenges and beneficially modulates the intestinal microbiota.
Microbes and animals have learned to co-exist and interact during the evolution. Biological functions between them are based on the molecular interactions. Size, shape and other physical properties of the molecules are of key importance for these ancient interactions also with yeast products. The cell wall components are opened and released for optimal availability to bacteria and immune cells by an optimized, unique acid hydrolysis process of Progut®. The patented whole yeast hydrolysate Progut® contains both high amounts of soluble oligosaccharides and the insoluble cell wall fraction.
Yeast cell wall contains mannoprotein, beta-glucan and chitin which all have a potential role in the gut. In an intact yeast cell these structures are cross-linked and weakly exposed to the microbes or immune cell receptors. This results in a product with outstanding amount of suitable molecular structures for bacterial and immunological interactions in the gut.
- Technical Details
Trains the immunity of young animals:
Progut® contains several immune stimulating compounds (β-glucan, mannoprotein and chitin structures) and has increased water-solubility for better visibility to immune receptors. It has shown to increase the recruitment of T-lymphocytes and the immunoglobulin production in the gut. Due to these functions it has enhanced the immune responses of young animals under challenge. Progut® trains the immune system of young animals to cope better with the challenges.
Pathogen Binding - Efficiently binds E. coli and Salmonella bacteria:
Balancing microbiota:
Progut® has shown to beneficially modulate the composition of gut microbiota in sows, piglets and broilers.