Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Animal Feed & Nutrition Functions
- Ingredients
- Saccharomyces Cerevisiae
- Technologies
Features & Benefits
- Labeling Claims
- Animal Feed & Nutrition Features
- Product Overview
Stronger Activation:
Progut® Extra is a new generation version of Progut® produced by stronger hydrolysis resulting in higher content of soluble, bioactive structures and enhanced biological responses.
Enhanced Function:
Higher content of the soluble molecular yeast structures enhances the efficacy in modulating immunity and both intestinal and ruminal microbiota.
Lower Inclusion – Same Performance boost:
Offers the same customer benefits than standard Progut® at lower rate of inclusion. Enhanced efficacy makes Progut® Extra especially suitable for challenging conditions and for ruminant applications.
- Progut® Extra for Poultry
Prevents salmonella and E. Coli problems:
- Progut® application in the last 2 weeks of production for broilers reduced Salmonella count in boot swab by almost one log compared to control.
- Progut had higher in vitro binding capacity of poultry related Salmonella and E. coli strains than the tested competing yeast products.
- Progut® reduced E. coli related mortality (salpingitis) in layers.
Solves dysbiosis or dirty eggs problems in laying hens:
- Progut® alleviated chronic enteritis in layers based on the improved performance.
- Progut® reduced E. coli related dysbiosis problems and dirty eggs in layers.
Improves broiler performance:
- In young broilers until 14 days of age Progut® improved feed conversion ratio by 2 points, and reduced mortality by 62%.
- During the 42 days growing period, Progut® improved feed conversion ratio by 2 points.
Modulates immunity:
- Supplementation of Progut® in breeder diet significantly improved immunity in chicken.
- Progut® increased the concentration of IgA in the chicken gut by 38%.
- In Eimeria challenged broilers Progut® increased secretion of interferon-gamma, but did not affect the unchallenged birds.
Practical Applications:
- Broilers: Starter 0.75 kg/ton, Grower 0.5 kg/ton, Finisher 0.3 kg/ton of feed.
- Turkeys: Starter 0.75 kg/ton, Grower 0.5 kg/ton, Finisher 0.3 kg/ton of feed.
- Layers: From the start until the peak of lay 0.7 kg/ton of feed
- Breeders: 0.7 kg/ton of feed
The recommended doses can be increased to double in challenging conditions.
- Progut® Extra for Pig
We call Progut® Extra a 3-in 1 product, for thanks to its unique hydrolysis Progut® Extra has a profound immune stimulation ability, it can bind with pathogens like E. coli and balance gut microbiota. At weaning, immature immune and intestinal system can affect the growth and feed efficiency of the piglets. Many stress factors associated with the weaning period, such as removing from the sow, changes in the diet, adapting to a new environment, mixing of piglets from different farms also lead to an intestinal dysfunction in piglets can be associated with proliferation of enterotoxigenic E. coli and post-weaning diarrhea. Progut® Extra has a proven record of performance improvement in wean piglets by reducing the risk of diarrhea, improve feed intake and FCR. Due to the stronger hydrolysis process Progut® Extra contains relatively higher amount of sugar structures which provide an alternative binding sites to bacteria and reduces the attachment of E. coli to gut mucus. However, Progut® Extra is fastening the immunomaturation of young animals by increasing the amount of immune cells in the intestinal epithelium and by increasing immunoglobulin production.
Prevents E.Coli Problems:
- Reduced fecal shedding of hemolytic E. coli in challenged piglets
- Higher in vitro binding capacity of pig related E. coli strains than the tested competing yeast products
- Higher prevention of E. coli attachment to piglet ileal mucus than the tested competing yeast products
- Reduced intestinal permeability increase under E. coli challenge ex vivo
Improves piglet performance:
- Improved FCR in weaners
- Improved growth and FCR in weaners
Prevents weaning diarrhea in piglets:
- Reduced risk of weaning diarrhea in E. coli challenged piglets
- Reduced diarrhea in E. coli challenged piglets
Improves sow and litter performance:
- Progut® Extra in sow feed before farrowing increased colostrum yield and fat, reduced farrowing duration, and numerically reduced pre-weaning mortality
- Progut® Extra in sow feed before farrowing numerically increased IgG in colostrum, piglet birth and weaning weights, improved litter uniformity, and reduced pre-weaning mortality
Modulates Immunity:
- Increased antibody titers against the sheep red blood cells in weaners, and tendency to increase IgG in serum 2 weeks post-weaning
- Increased concentration of IgA and amount of CD4 and CD8 + lymphocytes in the gut
- Increased production of IP-10 cytokine (chemo-attractant) in dendritic cell model in vitro (Bioplex immunoassay)
Practical Applications:
Piglets Training of immunity, prevention of weaning diarrhea problems and improvement of performance of weaned piglets
• Suckling piglets: 1.5 kg/ton
• From weaning to 2 weeks post-weaning: 1.0 kg/ton
• Оlder piglets (2 weeks post-weaning >): 0.5 kg/ton
Sows Improvement of litter performance through improved colostrum yield and quality. Minimum one week before farrowing until end of lactation: 0.8 kg/ton
The recommended doses can be increased to double in challenging conditions.- Progut® Extra for Young Ruminants
Progut® Extra has shown performance benefits in applications for calves, goat kids and lambs. Along with the beneficial effects in the gut Progut® Extra enhances rumen development and function.
Trains the immunity to respond better to challenges:
Progut® Extra enhanced response to bacterial and viral challenges, measured by increased amounts of bacterial and viral specific IgA in the serum of calves challenged with Hog cholera and Erysipelothrix insidiossa.
Effective in beef cattle:
- Progut® Extra increased feed intake and growth under stressful conditions after transportation and vaccinations.
- Progut® Extra improved growth of steers.
Effectively binds calf specific E. Coli and salmonella:
- Progut® Extra showed an outstanding capacity to bind calf specific E. coli and Salmonella bacteria in comparison to competing yeast cell wall products.
Reduces diarrhea risk:
- Progut® Extra addition in starter feed improved fecal and health scores of young calves.
Practical Application:
CALVES, LAMBS AND GOAT KIDS Training of immunity, prevention of diarrhea problems and improvement of performance
• Starter feeds: 0.5–1.5 kg/ton of feed
• Milk replacers: 1.5 kg/ton of feed
BEEF CATTLE For improving feed intake, feed efficiency and growth especially under stressful conditions - 4 to7 g/d- Progut® Extra for Dairy Cows, Goats and Sheeps
Enhances rumen fermentation:
- Progut® has consistently increased the production of gas, microbial biomass and volatile fatty acids both in vitro and in vivo.
- Improved rumen fermentation increases the amount of protein and energy that is available for the ruminant.
Improves milk yield and feed efficiency:
- Progut® has increased milk yield of dairy cows on average by 1.8 kg/d.
- It has improved milk, protein and fat yields throughout the lactation with different diets and concentrate:silage ratios.
- Progut® has increased milk yield also in dairy sheep and goats.
- Addition of Progut® in the diet has improved feed efficiency by 5–8 % in dairy cows.
Supports the immunity:
- Progut® has reduced somatic cell scores in milk.
- It has accelerated recovery of cow’s immune status from calving.
Applications:
For improving milk yield and feed efficiency and for supporting immunity
- Cows: 5–15 g/d
- Sheep and goats: 0.5–1.5 g/d
- Progut® Extra for Beef Cattle
- Progut® has improved daily weight gain of steers
- Progut® has increased feed intake and growth under stressful conditions after transportation and vaccinations of beef cattle
Practical Application:
- For improving growth and feed efficiency of beef cattle: 4–7 g/d
- Progut® Extra for Aquaculture
- Modulation of immunity
- Improved condition of intestinal epithelium
- Improved performance of fish and shrimp
Practical Applications:
- In fish and shrimp: 0.4–1.2 kg/ton of feed
- Production Features
- Production process grants a stable content of the bio-active compounds
- Strict internal and external quality control
Applications & Uses
- Markets
- Applications
Regulatory & Compliance
- Certifications & Compliance
- Certifications & Registrations
- GMP+ (Nastola) and ISO certified
- A feed material status in European Union, registered in several countries beyond EU
Technical Details & Test Data
- Technical Details
Progut® Extra is a new generation yeast product.
- It improves rumen microbial fermentation by increasing the production of microbial biomass and volatile fatty acids, especially propionate, thus improving feed efficiency, milk yield and growth performance.
- Trains the immunity of young animals, efficiently binds E. coli and Salmonella bacteria and beneficially modulates the gut microbiota at a low inclusion rate.
- Supports the immunity of ruminants.
- Technical Details
Action in the Rumen:
Progut® Extra has increased the production of gas, microbial biomass and short chain fatty acids, especially propionic acid in numerous in vitro simulation trials with different diets and ratios of concentrate to silage. The in vitro effects have been verified with the in vivo trials in fistulated cows. Improved rumen fermentation increases the amount of protein and energy that is available for the ruminant and thus improves feed utilization. In the simulation trials, Progut® Extra stimulated those bacterial groups that were active at the given phase of the simulation. This may indicate Quorum Sensing signaling systems involvement in the regulation of bacterial density. Microbes can produce and release chemical signal molecules by which they communicate and regulate different physiological activities. The hypothesis is that rumen bacteria can recognize increased amount of yeast cell structures as competition and grow in number for better competence.
Action in the gut:
Immunity: Progut® Extra contains several immune stimulating compounds (β-glucan, mannoprotein and chitin structures) and has increased water-solubility for better visibility to immune receptors. It has shown to increase the recruitment of T-lymphocytes and the immunoglobulin production in the gut. Due to these functions it has enhanced the immune responses of young animals under challenge. Progut® Extra trains the immune system of young animals to cope better with the challenges.
Pathogen Binding: Progut® Extra contains similar carbohydrate structures, such as mannose-rich glycoproteins, as the intestinal mucus. These structures in available form provide attachment sites for the fimbriae of pathogens, thus preventing them from attaching to intestinal mucosa. The product has shown outstanding efficacy in preventing the adherence of E. coli and salmonella to intestinal mucus.
Modulating microbiota: n addition, Progut® Extra has shown to beneficially modulate the composition of gut microbiota in sows, piglets and broilers.
Immunity for ruminants:
Progut® Extra has reduced somatic cell scores in dairy cows. It has also increased the IgA levels in the colostrum and accelerated recovery of cow’s immune status from calving when fed to dry cows. In calves, Progut® Extra has enhanced immune responses to bacterial and viral challenges. These immune responses can be explained by the high content of several immune stimulating compounds (β-glucan, mannoprotein and chitin structures) which are available to immune receptors due to the unique hydrolysis process.