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HEPPE MEDICAL CHITOSAN GMBH Chitin

Chitin belongs to the biopolymer group and its fibrous structure is similar to cellulose. Chitin is the second most common regenerative polysaccharide after cellulose.

Chemical Name: Chitin

Functions: Anti-Fungal Agent, Anti-Microbial Agent

CAS Number: 1398-61-4

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Identification & Functionality

Chemical Name
Pharma & Nutraceuticals Functions
Molecular formula
(C₈H₁₃NO₅)ₙ
CAS No.
1398-61-4
EC No.
215-744-3
Origin

Chitin was first isolated and characterized in 1811 by the chemist and botanist Henry Braconnot.

Occurrence in Nature
  • In the exoskeleton of animals such as shrimp, crabs, krill, squid and insects or in cell walls of fungi, yeast and other microorganisms.
  • The amount of chitin in marine biomass alone is approx. 10- 107 tons.
  • A distinction is made between alpha, beta and gamma chitin, which have different mechanical properties depending on the arrangement of the polymer chains.
    • Alpha: alternating antiparallel arrangement of polysaccharide chains (crustaceans)
    • Beta: parallel chain arrangement (squid)
    • Gamma: two parallel chains statistically alternating with an antiparallel chain (fungi)
Chemical Structure

HEPPE MEDICAL CHITOSAN GMBH Chitin - Chemical Structure

Chemical Structure (50% deacetylizated)

HEPPE MEDICAL CHITOSAN GMBH Chitin - Chemical Structure (50% Deacetylizated)

Features & Benefits

Product Highlights

Chitin is a nitrogenous polysaccharide. It belongs to the group of biopolymers. Monomers of chitin are called acetyl-glucosamine because the acetyl group is bonded to the nitrogen atom. Monomers are cross-linked in the polymer „beta-1,4 glycosidic“. This denotes to type and manner and structure in which the monomers are bonded with each other. There are three different kinds of structure in which chitin occurs in nature: as alpha,beta and gamma chitin. Chitins have those different arrangements of polymer chains which provthathem with differing properties and can be found in various organisms:

  • Alpha chitin: in arthropods, crustaceans
  • Beta chitin: in molluscs, such as squids
  • Gamma chitin: a mixture of alpha and beta structures, notably in cephalopods
Function of Chitin in Nature
  • Supporting function (structural substance)
  • Protection of soft parts (offers protection to inner organs)
  • Prevention of loss of fluids
Biodegradability

Biodegradable through the enzymes chitinases and lysozyme to chitobiose and through the chitobiases to monosaccharides.

Applications & Uses

Potential Applications

Chitin can be applied either directly or further processed into various derivatives. Two of the most important derivatives are chitosan and glucosamine.

Chitin Application in Cosmetics

As carboxymethyl chitin (moisturizers, changes flow properties), antistatic effect due to cationic properties (hair products).

Chitin Application in Medicine/Pharmaceutics
  • Wound and burn treatment
  • Hemostatic for orthopedic treatment of broken bones
  • Viscoelastic solutions for ophthamology and orthopedic surgery
  • Abdominal adhesions treatment
  • As antibacterial and antifungal agents and for treatment of mucous membranes
  • In tumor therapies
  • In micro surgery, neurosurgery
  • For treatment of chronic wounds, ulcers and bleeding (chitin powder)

Properties

Insoluble in
Water, Organic Solvents, Weak Acids, Lye
Soluble in
Conc. Formic Acid, Methane Sulfonic Acid