BPF®

Identification & Functionality

Ingredient Name

Bergamot Extract

Food Ingredients Functions

Supplement

Pharma & Nutraceuticals Functions

Dietary Supplement,

Phytochemical

Ingredients

Bergamot Extract

Technologies

Food Ingredients,

Pharmaceuticals & Nutraceuticals

Product Families

Pharmaceuticals & Nutraceuticals — Nutraceuticals & Supplements

Phytochemicals & Plant Extracts,

Supplements & Functional Ingredients

Food Ingredients — Nutrition & Fortification

Functional Ingredients,

Phytochemicals

Food Ingredients — Whole Foods, Extracts & Premixes

Plant & Herb Products & Extracts

Chemical Structure

BPF® is the most widely studied extract of the Bergamot fruit’s juice and albedo, which has a unique profile of flavonoids and glycosides, such as neoeriocitrin, neohesperidin, naringin, rutin, neodesmin, rhoifolin, and poncirin. These flavonoids are clinically proven to help maintaining healthy cholesterol, and promoting healthy weight management. Recent studies showed that the Bergamot Polyphenolic Fraction (BPF®) represents a viable alternative to statins in patients who are intolerant to these drugs or in subjects who discontinue the treatment due to side effects. It has been proved that BPF® counteracts oxidative stress and suppresses inflammation in endothelial cells, thus inhibits plaque formation, and improvs arterial responsiveness.

Features & Benefits

Benefit Claims (Health)

Anti-Inflammatory,

Cardioprotective,

Decreases LDL Cholesterol

Food Ingredients Features

Anti-Inflammatory,

Reduction in Cholesterol

Applications & Uses

Markets

Food & Nutrition

Applications

Food & Nutrition — Nutrition & Well Being

Nutraceuticals & Supplements

Food & Nutrition Applications

Nutraceuticals

BPF ® Potentiates The Effect Of Statins

• High cholesterol represents the most relevant risk factor for developing Coronary Artery Disease and Stroke.
• Current Pharmacological Treatment of High Cholesterol is effective in reducing Cardiovascular Risk but is ac- companied by relevant side effects.

	Total Chol	LDL-C	HDL	Trygl
Basal	278 ±4	191 ±3	38 ±2	238 ±5
Placebo	275 ±4	190 ± 2	38 ± 3	235 ±5
Rosu 10mg/day	195 ± 3*	115 ± 4*	42 ± 3*	200 ± 4*
Rosu 20mg/day	174 ± 4*	87 ± 3*	48 ± 3*	202 ± 5*
BPF 1g/day	191 ± 5*	113 ± 4*	45 ± 4*	165 ± 3*
Rosu 10mg+ 1g BPF	172 ± 3*	90 ± 4*	52 ±4*	152 ± 5*

BPF® Effective For Cholesterol

• High cholesterol represents the most relevant risk factor for developing Coronary Artery Disease and Stroke.
• Current Pharmacological Treatment of High Cholesterol is effective in reducing Cardiovascular Risk but is ac- companied by relevant side effects.

	Total Chol	HDL-C	LDL-C	Triglycerides	Blood Glucose
Placebo	0.14%	+1.2%	-1.1%	+0.1%	+0.5%
BPF ® (500mg/Day)	21.8%	+22.9%	-24.1%	-32%	-18.9%
BPF ® (1000mg/Day)	-29.4%	+40.1	36.0%	41%	-22.4%

Technical Details & Test Data

BPF® Enhances Nitric Oxide Release In Athletes