Knowde Enhanced TDS
Identification & Functionality
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 84775-70-2
- EC No.
- 283-899-4
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Highlights
- Promoting the secretion of R-spondin 1
- Suppressing the secretion of hair loss factor DKK 1
- Human hair follicle elongation
- Hair growth in clinical trials
Applications & Uses
- Markets
- Applications
- Application Format
- Hair Care Applications
Properties
- Physical Form
- Appearance
- Light yellow to yellow liquid
- Odor
- characteristic odor
- Specifications
| Value | Units | Test Method / Conditions | |
| Arsenic Content | max. 2 | ppm | — |
| Heavy Metals Content | max. 20 | ppm | — |
| Residue on Evaporation | 0.1 - 0.3 | w/v% | — |
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Focus on “R-spondin 1” which activates the outer root sheath, the foundation of hair follicles
“R-spondin 1” is a protein involved in the regeneration of organs and tissue and is currently increasing attention in the field of regenerative medicine. In the field of hair science, “R-spondin 1” activates the foundation of hair follicles, known as the outer root sheath, which is important in making thick hairs that do not come out easily. This led to the development of “BURGEON-UP” which is the hair growth material applied for the first time.
As “BURGEON-UP” also suppresses the mechanism of action of male hormones, it activates follicles while also preventing hair loss. In addition to male hair loss, “BURGEON-UP” is expected to work on female hair loss.
- Suppresses the action mechanism of male hormones (protecting the Anagen) and activates hair follicles (stimulating the Anagen).
In hair tissues, the tissue regenerationrelated protein R-spondin 1 binds with the receptors (LGR5) in the outer root sheath, which is the foundation of hair follicles; activates cells; and stimulates hair growth*. Additionally, R-spondin 1 suppresses the production of the hair loss factor DKK 1, which works in the mechanism of action of male hormones.
BURGEON-UP is expected to have adouble punch benefits as promotingthe secretion of R-spondin 1 from dermalpapilla cells to stimulate hair growth while also preventing hair loss caused by malehormones.
- Promoting the secretion of R-spondin 1
0.5% and 1% BURGEONUP was added to cultured human dermal papilla cells, culture supernatant was collected 2 days later, and R-spondin 1 protein content was measured using ELISA. BURGEON-UP was shown to increase the R-spondin secretion and activate outer root sheath cells.
- Suppressing the secretion of hair loss factor DKK 1
0.25% and 0.5 BURGEON-UP were added to cultured human dermal papilla cells in the presence of DHT, the culture supernatant was collected 3 days later, and the DKK 1 protein
amount was measured using ELISA.
- Hair growth in clinical trials
A lotion containing 2 BURGEON-UP or a control lotion was applied to the head of 40
male test subjects aged between 20 and 55 living in India twice a day for 6 months. Their
hair condition was measured using TrichoScan. Total hair number, hair growth rate and hair
thickness were significantly increased in the area of BURGEON-UP applied.
