Incospharm Corporation rhEGF

Incospharm Corporation rhEGF is a member of the EGF-like family of proteins. It stimulates the growth and differentiation of fibroblasts and epithelial cells, and plays a role in the development and regeneration of various tissues. EGF is synthesized as a precursor protein that remains anchored to the cell surface. Release of the soluble form occurs through a process known as ectodomain shedding, which involves cleavage of the extracellular domain by the proteins disintegrin and ADAM17. EGF signals via EGF receptor (EGFR, ErbB1 or HER1), which is a type 1 tyrosine kinase receptor and can also bind several other EGF-like proteins. Binding of EGF to EGFRs trigger receptor dimerization, autophosphorylation and internalization of the receptor-ligand complex. Recombinant human Epidermal Growth Factor, from E.coli, is a 6.2 kDa protein containing 53 amino-acid residues.