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AdipoSOL™ 2000 is a novel anti-photoageing ingredient that protects the skin from UV stress through autophagy induction and adiponectin expression in skin cells. Shifting of MED proves its skin protection against UV. UV exposure decreases the expression of adiponectin, a well-known adipokine, secreted by adipocytes, leading to the exacerbation of photoageing by stimulating MMP-1 expression and inhibiting procollagen synthesis. Thus the repeated skin damage and imperfect repair caused by UV exposure results in “photoageing” and “inflammageing”.