Knowde Enhanced TDS
Identification & Functionality
- Cosmetic Ingredients Functions
- Technologies
Features & Benefits
- Benefit Claims
- Product Highlights
- Activates autophagy
- Increases adiponectin expression
- Recovers adiponectin reduction
- Decreases MMP-1 expression
- Decreases expression and secretion of inflammatory factors
Applications & Uses
- Markets
- Applications
- Sun Care Applications
- Application
- Suncare (Sun-Block creams and lotions)
- Skincare (After-Sun Products)
- Anti-aging
- Anti-inflammation
- Redness relief
- Recommended Dosage
- 1~2% for cream and lotion formulation
Properties
- Appearance
- Clear liquid
Technical Details & Test Data
- Efficacy
Activates Autophagy
- Autophagy reduces the inflammation and oxidative stress caused by various environmental stresses including UV.
- Enhancing of autophagy leads to anti-aging effect.
Increased production of autophagy marker LC3 by AdipoSOL™ 2000 was observed by confocal microscopy ( h u m a n d e r m a l f i b ro b l a s t , 2 4 h r ) . LC 3 p u n c t a o f autophagosome were labeled with green spots.
Increases Adiponectin Expression through Autophagy Activation
Increased Adiponectin expression (red color) by AdipoSOL™ 2000 was observed by confocal microscopy
Effect of autophagy inhibitor on AdipoSOL™ 2000-mediated adiponectin expression was measured by western blot.
- Adiponectin is a typical adipokine secreted from adipocytes, of which expression is reduced in UV-exposed skin.
- Increment of adiponectin expression in the effectiveness of AdipoSOL™ 2000 is reduced by treatment of Autophagy inhibitor.
Decreases MMP-1 Expression
- In 3D skin model (MatTek EpiDermFT™), immunohistochemical analysis detected reduced MMP-1 level in both keratinocytes and dermis after AdipoSOL™2000 treatment for 24hr.
Recovers Collagen Reduction
- Increased collagen was measured by ELISA using culture supernatant in 3D skin model (MatTek EpiDermFT™). 3D skin was treated 100 uM AdipoSOL™ 2000 for 24hr and then UVB 100 mJ/ cm2. After UVB exposure, 3D skin was incubated for 4 days.
Decreases UVB-induced Expression and Secretion of Inflammatory Factors
Human epidermal keratinocytes and 3D skin model (MatTek EpiDermFT™) were incubated 100 uM AdipoSOL™ 2000 for 24hr and then exposed to UVB 100 mJ/cm². Anti-inflammation effect was detected by ELISA (Left) and RT-PCR (Right).
Shifts MED
- Redness formation in topical skin application of AdipoSOL™ 2000 is less severe than vehicle.
- 2 weeks pre-treatment of AdipoSOL™ 2000 shows shifting of MED by 56.2%
Reduces Skin Redness
- 12 volunteers were applied with 100ppm AdipoSOL™ 2000 in cream or vehicle for 4 weeks.
- AdipoSOL™ 2000 reduces skin Redness by 13.23% than before. Redness measured using Chromameter.
Storage & Handling
- Shelf Life
- 12