Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Bioptimized™ Guava Inhibits the Activation of NFkB
- Cellular senescence is the cause of the production of specific molecules known as the Senescence Associated Secretory Phenotype (SASP) factors “toxifying” the skin tissue environment, thus accelerating the age-dependent tissue disorganization.
- The production of SASP factors is controlled by the synthesis regulator NFkB which is rapidly activated as cells become senescent.
- Bioptimized™ Guava is an active ingredient that inhibits the activation of NFkB and the production of SASP factors preventing skin aging signs appearance.
- Actions & Efficacy
- Inhibition of NFkB activation – Bioptimized™ Guava blocks the degradation of the NFkB inhibitor, IkB and thus locks NFkB in an inactive configuration
- Inhibition of eotaxin production
- Inhibition of COX-2/PGE2 pathways
- Inhibition of iNOS/Nitric oxide pathways
- Increase in skin firmness and elasticity
- Decrease in wrinkle depth
- Decrease in Physiological and UV-induced Skin Oxidative damage
- Product Highlights
- 100% water soluble
- Preservative-free
- Made with non-GMO propanediol
- Recommended concentration in formulation: 1 - 3%
- Key Features
- Guava leaves are harvested from Jeju Island, that is created entirely from volcanic eruptions approximately 2 million years ago. It has humid subtropical climate with a unique soil composition and is the habitat of unique species of plants.
- BioptimizedTM Guava is an inhibitor of cellular senescence, a condition involved in the acceleration of the aging process, as tissue degeneration, oxidative damage, chronic inflammation.
- It slows down the causes of skin aging, not just the effects.
Applications & Uses
- Markets
- Color Cosmetic Applications
- Skin Care Applications
- Sun Care Applications
- Use Level
- 0.5 - 3%
- Applications
- Anti-aging, anti-wrinkle
- Diminution of senescence-related chronic inflammation
- Reduction of skin damage induced by senescence
- Prevention of tissue disorganization caused by the aging process
- Reduction of age-related SASP side effects
- Protection/repair of environmental damages
- Anti-pollution
- Sun care
- After sun care
- Sunscreens
- Formulation Procedures
Incorporate in a formulation at 40°C max, during cooling phase or at the end of the preparation.
Properties
- Physical Form
- Soluble in
- Water, Glycerin, Propylene Glycol
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Technical Information
- Clinical Anti-Aging Efficacy
Bioptimized™ Guava prevents the appearance of skin aging signs
Skin Elasticity
Skin Firmness
Wrinkle Depth
The SASP factors Eotaxin and COX-2 (PGE2) cause degradation of extracellular matrix and dermoepidermal junctions resulting in loss of tone and wrinkle appearance.
Primos 3D – periocular area
Bioptimized™ Guava inhibits Eotaxin and COX-2 (PGE2) pathways reducing wrinkle depth and improving skin elasticity and compactness.
BioptimizedTM Guava reduces the skin oxidative damage.
Physiological Skin Oxidative damage
UV-induced Oxidative damage
*MDA (Malonyldialdheyde) is one of the main products of lipid peroxidation. Its concetrantion in a biological system is a good index of its lipo-peroxide damage
The production of free radicals is a physiological event and occurs typically in cellular biochemical reactions, especially in those that use oxygen to produce energy.
Oxidative stress can damage cells, proteins, and DNA, contributing to aging.
Free radicals can also be produced due to external factors (e.g., UV).
The reactive nitrogen species, including Nitric Oxide (NO), participate in oxidative damage, DNA damage, and free radicals production, which result in chronic skin inflammation and a decrease in skin barrier function.
Bioptimized™ Guava reduces both physiological and UV-induced oxidative damage preventing premature skin aging signs appearance.
- Anti-Aging Booster Activity
BioptimizedTM Guava can be used as the main ingredient for a strong anti-aging activity or in combination with “traditional” anti-aging active ingredients to boost their efficacy
Primos 3D – periocluar area
Primos 3D – periocluar area
Bioptimized™ Guava action in preventing skin aging signs results in improving the effectiveness of «traditional» anti-aging active ingredients.
- Bioptimization: Improving Technology
BioptimizedTM Guava is an extract of Guava leaves “biologically-optimized” with a Saccharomyces lysate to enhance its biological properties. BioptimizedTM Guava performs better than an extract from normal Guava leaves. BioptimizedTM Guava is a unique bio technology derived ingredient that targets numerous pathways involved in skin cell senescence. It blocks the activation of the master regulator NFkB by preventing the degradation of its inhibitor, IkB. Consequently, NFkB is maintained inactive and does not translocate to the cell nucleus. BioptimizedTM Guava inhibits the Eotaxin, COX-2/PGE2 and iNOS pathways all under the control of active NFkB regulation.
Control
Inactive form of NFkB located in the cytoplasm
Senescence
Active form of NFkB located in the nucleus
Standard Guava extract
Standard Guava extract, partially inhibits NFkB activation
Bioptimized™ Guava
BioptimizedTM Guava completely inhibits NFkB activation
- Test Data
Bioptimized™ Guava inhibits the production of the chemoattractant Eotaxin
- No collagen breakdown
- Maintenance of the integrity of the dermo-epidermal junction
The reduction in PGE2 production parallels the decrease in COX-2 expression in the presence of Bioptimized™ Guava
- No collagen breakdown
- No elastin degradation
The reduction in NO production parallels the decrease in iNOS expression in the presence of Bioptimized™ Guava
- No oxidative damage
- No inflammatory reaction
Storage & Handling
- Shelf Life
- 3 Years
- Storage and Shelf Life Conditions
- In original sealed containers, in a cool and dry place, protected from light.
- Cloudiness or sedimentation is normal and may be resolved by rotating the unopened drum.
- 3 years, stored unopened in original containers.
- Once opened the shelf life is limited by temperature, light and exposure to air.