Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Cosmetic Ingredients Functions
- CAS No.
- 84650-12-4
- EC No.
- 283-493-7
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- In Vitro & Clinical Actions
- Inhibition of tyrosinase activity (Oxidation of L-DOPA)
- Inhibition of melanogenesis (Human melanocytes in culture)
- Reduction of melanin pigmentation (Reconstructed epidermis)
- No toxicity to skin cells (Cellular Viability - Human melanocytes in culture)
- Significant skin lightening after 28 days (Mexameter®)
- Digital aging response – protection against oxidative caused by blue light exposure (ROS assay)
- Product Highlights
- Panax ginseng fraction enriched in ginsenosides
- Preservative-free
- Water soluble
- Recommended use level: 1-2%
- Key Features
- Prevents skin melanocytes from producing and accumulating melanin pigments.
- Protects against oxidative stress and dull complexion caused by blue light exposure, preventing “Digital-aging”.
Applications & Uses
- Markets
- Applications
- Color Cosmetic Applications
- Personal Hygiene Applications
- Skin Care Applications
- Sun Care Applications
- Use Level
- 0.2- 2%
- Applications
- Skin whitening
- Skin lightening
- Even complexion
- Homogenization of skin tone
- BB cream
- CC cream
- Feminine intimate care
- Sun care
- Depigmented products for sensitive areas
- Functional make-up
- Formulation Procedures
Incorporate in a formulation at 40°C max, during cooling phase or at the end of the preparation.
Properties
- Physical Form
- Soluble in
- Water, Glycerin, Propylene Glycol
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Technical Information
- Melanogenesis in Reconstructed Epidermis
- Reduction of melanin granule density
- Cellular Viability
Human melanocytes in culture
- No sign of cytotoxicity on melanocytes
- The skin whitening effect is given by GinsenoLite™-G down-regulation of Tyrosinase activity and melanogenesis process.
- Skin Melanin Index
Ginsenolite™-G improves skin lightening after 28 days
- Skin Erythema Index
- No signs of erythema, like using a placebo
- Digital Aging Protection
ROS assay on human keratinocytes in culture - blue light-induced oxidative damage
ROS assay on Reconstructed Human Epidermis – blue light-induced oxidative damage
In the negative control (NC), blue light exposure causes the production of Reactive Oxygen Species (ROS).
- GinsenoLite™-G significantly reduces the ROS production of cells or tissues stimulated with blue light
- GinsenoLite™-G has a protective activity against Digital Aging, preventing blue light induced damage
- Inhibition of Tyrosinase
Evaluation of Tyrosinase activity in human melanocytes by measuring the rate of oxidation of L-DOPA
The enzyme Tyrosinase synthesizes melanin pigments by oxidizing the precursor L-DOPA
- Ginesnolite™-G reduces skin pigmentation by inhibiting tyrosinase
- Inhibition of Melanogenesis
Through the biochemical process of Melanogenesis, the pigment melanin is produced in melanosomes by melanocytes.
Human melanocytes in culture
- Ginesnolite™-G significantly reduces the melanogenesis process
Storage & Handling
- Shelf Life
- 3 Years
- Storage and Shelf Life Conditions
- In original sealed containers, in a cool and dry place, protected from light.
- Cloudiness or sedimentation is normal and may be resolved by rotating the unopened drum.
- 3 years, stored unopened in original containers.
- Once opened the shelf life is limited by temperature, light and exposure to air.