Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Cosmetic Ingredients Functions
- Technologies
Features & Benefits
- Benefit Claims
- Labeling Claims
- Biomimetic Hydroxyapatite Functionalized with Cationic Surfactant (QAC)
Technology based on the use of the HAP delivery system able to deliver a hygienizing surfactant on the skin through a time controlled kinetics (4 hours)
- International patent
- Hygienizing active for cosmetics: skin and hand care.
- Long lasting bio-protection against biological agents.
- Single application protects the skin up to 4 hours.
- Proven activity vs Bacteria and Viruses (including Coronavirus and Influenza)
- Promotes skin barrier integrity and epidermal balancing.
- Local microbiota respectful
- Cationic Surfactant- Quaternary Ammonium Compound (QAC)
- Protective: Works as cationic surfactant by impacting biological walls and membranes of microorganisms and keeping the skin clean.
- Preventive: Promotes inactivation of viruses and bacteria by destroying the viral envelope or bacterial membrane (this mechanism of action does not induce resistance selection)
- Safe: Widely used in cosmetics and food as preservative and contained in oral care products, it possesses an optimal safety profile.
- Benefits Of Kalygenetic in Skin Care
Kalhygienic:
- Ensure a long-lasting effect by gradually releasing active concentrations of QAC on the skin following a pH dependent kinetics.
- Promotes Skin rebalancing, elasticity and decreases skin roughness.
- Increases skin firmness and reduce skin stretchability.
- The QAC linked to it does not allow potentially pathogenic bacteria.
Skin Care Claims:
- Long-lasting skin protection against biological agents
- Deep hygiene
- Prevention against biological agents
- Improves skin barrier and nourishes skin
- Prevents acne, seborrhea (through sebum adsorption), excessive perspiration
- Sensorial improvement when compared to alcoholic sanitizers.
- Microbiota respectful
Applications & Uses
- Markets
- Applications
- Personal Hygiene Applications
- Skin Care Applications
- Kalhygienic Use Rationale
Solving with cosmetics creams & gels the limits of sanitizers:
- Persistency of Action:
- Mineral able to deliver in Long Term Hygienizing Surfactant (QAC) on the skin
- 4 hour proven action following cosmetics cream application: It works like a “leave on soap” to apply only once that does not irritate the skin and keeps it hygienized in long term.
- Skin Friendly Nature
- Formulated in emulsion, promotes several beneficial effects on the skin.
- In comparison to traditional soaps and sanitizers its use does not dry out the skin, since it is used in cosmetics emulsions, and has been proven to rebalance the skin improving its smoothness, elasticity and compactness of the barrier.
- Persistency of Action:
- Application Fields
Antiage:
Anti-aging creams are predominantly cosmeceutical skin care products marketed with the promise of making the consumer look younger by reducing, masking or preventing signs of skin aging. These signs are laxity (sagging), rhytids (wrinkles), and photoaging, which includes erythema (redness), dyspigmentation (brown discolorations), solar elastosis (yellowing), keratoses (abnormal growths), and poor texture. Kalichem proposals are working against the aging, preventing or reversing it.
Body Care:
Is the range of practices that supports body skin integrity, enhances its appearance and relieves skin conditions. A common practice that enhances the body skin appearance includes the use of cosmetics (i.e. slimming products, antistrecth markrks, …). Skin care is a routine daily procedure in many settings, such as skin that is either too dry or too moist, and prevention of skin injuries. Body care needs physiological, respectful and effective raw materials.
Microbiota Care:
Human microbiome, previously referred to as human microflora, or human bacterial flora, has been known for decades. Microflora, or as we now call it more precisely microbiota, is in fact the assemblage of the commensals microorganisms present in a defined environment. Former approaches to Microbiota were not reproductible or had a very low specifity, making all the formulation efforts useless. Kalichem’s Microbiota ingredients are very effective, bacteria free, formulator friendly ingredients, taking care of our Microbiota.
Skin Care:
Is the range of practices that supports skin integrity, enhances its appearance and relieves skin conditions. A common practice that enhances the appearance, includes the use of cosmetics. Skin care is a routine daily procedure in many settings, such as skin that is either too dry or too moist, and prevention of skin injuries. Skin care needs physiological, respectful and effective raw materials such as Kalichem’s actives an emulsifiers.
Properties
Technical Details & Test Data
- Product Innovation Trends
Sanitizers With Persistent Effects:
Alcohol based sanitizers are effective, but easily evaporate, thus loosing long-term efficacy. Thus, Kalhygienic Skin Sanitizers with persistent effects containing ingredients with skin long lasting protective properties to
- Extend the protective activity.
- Boost the hygienizing efficacy.
- Leave a protective barrier on skin's surface.
Skin-friendly Hand Sanitizers:
Continuous use of alcohol-based sanitizers can leave skin dry, red and damaged. Thus, Kalhygienic skin-friendly hand sanitizers containing ingredients with skin conditioning properties to:
- Form alcohol-free product
- Exert beneficial activity on skin
- Reduce skin irritation
- Biomimetic Hydroxyapatite: An Innovative Delivery System
- Exclusive know-how of hap production by kalichem.
- Compared to its synthetic stoichiometric form, it chemically shows higher reactivity, solubility, superficial area and lower crystallinity.
- Its peculiar reactivity and solubility make it an ideal delivery system for organic and inorganic substances
- When formulated at neutral pH- values it keeps its crystalline form and keeps the actives to deliver incorporated into its crystal structure.
- When exposed at skin acidic pH- the low dissolution of its crystals enables to deliver on a time- controlled basis the actives incorporated in it, promoting a long lasting release
- Biomimetic HAP As QAC Controlled Delivery System
An Active delivery system for skincare applications:
- Biomimetic hap is able to promote QAC release through a time-controlled pH dependent mechanism.
- QAC remains stably incorporated into HAP at pH between 7-8 in formulations
- When the product is applied on areas with lower pH (e.g. Skin, pH ~ 5.5), the pH decrease induces the delivery of QAC by modifying the kinetics of release.
- Biomimetic Hydroxyapatite: Benefits for Skin
The applications of Biomimetic Hydroxyapatite (6%) on skin promotes:
By reducing Visco-elastic ratio Biomimetic Hydroxyapatite:
- Increases skin firmness
- Increases the integrity of the skin barrier
- Kalichem’s Tests: Efficacy of Kalhygienic
Ref: Test Type Properties Time Target Microorganism % of Use Functionalized Biomimetic
HydroxyapatiteTransmission Electron Microscopy
Activity on Viral Envelope
1 hr Corona Virus
10%
4 hrs Cationic Surfactant-
Quaternary Ammonium CompoundInfectivity Assay (PREN 14476:2011)
Virucidal Activity
1 hr 4 hrs - Activity Of Kalhygienic Vs Coronavirus
Functionalized Biomimetic Hydroxyapatite Transmission Electron Microscopy (EM) studies showed that:
- Kalhygienic (10%) works effectively in disrupting viral envelope of a selected strain of coronavirus after 1 hour treatment.
- After 4 hours alteration results significantly increased.
- Infectivity Assay Vs Coronavirus
Cationic Surfactant Quaternary Ammonium Compound: Evaluation of Virucidal Activity according to European norm PREN 14476:2011. The assay allows to evaluate the ability of the test substance to inhibit growth and replication of viral particles in target cells
Test: Ability to reduce replication of a selected strain of coronavirus in cells after 1 hour and 4 hours treatment respectively. Viral particles were titred by using karber method.
