Knowde Enhanced TDS
Identification & Functionality
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Information
Skin Microbiota care & Wellness For:
- Skin care and emulsions
- Toiletries
- Cosmeceuticals and medical devices
Categories:
- Deodrants
- Functional Actives
- Kalibome Postbiotics: New Concepts
• Concentrated and reproducible postbiotics complex
• Obtained by controlled bio fermentation , finalized to select a specific actives output
• No bacterial fragments toxins , only ferment actives
• Total absence of side effects and maximum tolerability
• No culture broth or living bacteria , preservatives free
• No interference with cosmetics preservatives
• Powder form
• Low concentration of use required (0.1 ÷ 0.5 %)
POST biotics
Concentrated biotech active specialties . Fermentation carried in minimal media & controlled conditions. No living bacteria, residual food or bacterial fragments. Direct beneficial effects on skin and microbiota. Highly reproducible composition. White, soluble, colorless, odorless powder with concentrated actives.
* Patented fermentation process
STRAINS ELECTION F OR POSTBIOTICS PRODUCTION
Postbiotics were obtained from Lactobacillus Paracasei a commensal microorganism that showed beneficial effects on host modulating the skin barrier efficiency , commensal microbiota eco system balance and epidermis wellness.- Kalibome Ecogenetic Targets
1) Microbiota balance control and biofilm formation prevention aimed to promote the skin microbiome ecogenetic equilibrium
2) Strengthening of skin barrier function against pathogens, pollutants, free radicals
3) Cytokine modulation in skin cells, to counteract environmental aggressive factors ( UV- B rays) and skin immune system disease, aimed to keep skin microbiota balance
4) Skin wellness stimulation (skin redensification as mechanism of defense against photo aging, hydration increase, soothing action, extensibility reduction and redness decrease)- Microbiota Balance
MICROBIOTA BALANCE: ECOGENETIC MODULATION AND BACTERIAL BIOFILM
CONTROL
Microbiota balance control and biofilm formation prevention is aimed to promote the skin microbiome ecogenetic equilibrium
The following tests show Kalibiome ecogenetic activity over two of the most representative skin pathogens and the effect that its action exerts on the skin barrier integrity.
TESTS
Bacterial biofilm inhibition of the pathogens:- Staphylococcus aureus (atopic dermatitis pathogen)
- Pseudomonas aeruginosa (skin infections pathogen, cosmetics contaminant)
Skin barrier integrity assessment after infection with pathogens
MICROBIOTA BALANCE: IMMUNE SYSTEM ACTIVITY MODULATION
Kalibiome ecogenetic cytokine release modulation is a key feature that allows to keep under control the harmful effects related to microbiota unbalance, infections, exposure to UV B rays inflammation and immune diseases (e g psoriasis)
Tests carried out on skin cells comparing the activity of Kalibiome ecogenetic vs control
TESTS
Anti inflammatory index calculation, obtained through the ratio of the induced expression of:- Interleukin 10
(anti inflammatory cytokine expressed by skin immune system cells)
- Interleukin 12p70
(pro inflammatory cytokine, actively involved in inflammation and skin immune system diseases)
Immune system modulation on TNF α
(pro inflammatory cytokine triggered after the skin exposure to pathogens and
UV B rays )- Key Attributes
Immunomodulation Tissue Regeneration Skin wellness Microbial Control Inflammaging
preventionSkin
regenerationHydration
increasePathogen
bacteria
biofilm
onsetMicrobiome
ecogenetic
balancingSkin
barrier
integrity
increaseTEWL
reductionSkin
microbiota
balancingAnti
pollutionDermis
redensifyingSkin
firmnessStrengthening
skin
defense systems
Applications & Uses
- Markets
- Applications
- Application Format
- Personal Hygiene Applications
- Skin Care Applications
- Treatment Product Applications
- Application Fields
- Antiage
- Microbiota Care
- Skin Care
- Body care
- Deodrants
- Applications
- Cosmeceuticals & medical device
(gynecological , dermatological and cosmeceutical
treatments for sensitive skin)- Toiletries & Sanitizers
(soothing , microbiota balancing and reinforcement)
- Skin care and emulsions
(microbiota balancing, anti aging , skin wellness, anti inflammaging , redness reduction and soothing)
Properties
- Microbiological Values
| Value | Units | Test Method / Conditions | |
| Total Microbe Count | 0 - 100 | UFC/g | Internal |
Technical Details & Test Data
- Testing skin repairing action IN VIVO TEST
• Skin echogenicity and redensifying
• TEWL, skin extensibility
• Redness reduction
Tests carried out on 20 Caucasian women Dosage: 0,2% application twice daily vs placebo for 6 weeks- Skin Redness Reduction
a*is a parameter calculated by the Chromameter that increases linearly with erythema
Measurement of mean variations of a* value were carried out (to assess the change of skin redness 48 and 72 hours after the removal of SLS patches) Kalibiome ecogenetic shows significant redness reduction against placebo and non treated area
Safety & Health
- Safety
SKINCARE & DEFENSE IN THE COVID 19 ERA
The first mode of transmission of Covid 19 is direct skin contact with infected people and contaminated surfaces
World Health Organization recommends to frequently wash and sanitize skin as
the first and more effective measure against Coronavirus infection
Due to these repeated treatments skin becomes dry, cracked and more sensitive to external aggressive factors
Protects the skin by:- Increasing skin defenses due to its immunomodulatory effect
- Rebalancing skin microbiota which protects skin from pathogens
- Promoting skin barrier function due to its skin tightening effect
- Reducing inflammation and promoting hydration thus counteracting sanitizing treatments side effects