Knowde Enhanced TDS
Identification & Functionality
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Information
In Only Six Weeks , It:
- Increases skin elasticity
- Increases skin hydration
- Provides simultaneous roughness reduction
Categories
Functional Actives
- Kalibome Postbiotics: New Concepts
• Concentrated and reproducible postbiotics complex
• Obtained by controlled bio fermentation , finalized to select a specific actives output
• No bacterial fragments toxins , only ferment actives
• Total absence of side effects and maximum tolerability
• No culture broth or living bacteria , preservatives free
• No interference with cosmeticspreservatives
• Powder form
• Low concentration of use required (0.1 ÷ 0.5 %)
POST biotics
Concentrated biotech active specialties . Fermentation carried in minimal media & controlled conditions. No living bacteria, residual food or bacterial fragments. Direct beneficial effects on skin and microbiota. Highly reproducible composition. White, soluble, colorless, odorless powder with concentrated actives.
*Patented fermentation process
STRAIN SELECTION FOR POSTBIOTICS PRODUCTION
Postbiotics were obtained from Lactobacillus Paracasei a commensal microorganism that showed beneficial effects on host improving the skin barrier integrity , commensal microbiota eco system balance and epidermis wellness.
- Kalibome Sensitive Targets and Objectified Action
1) Improvement of skin barrier integrity through increased expression of ZO 1 tight junction and epidermal hyaluronic acid synthesis increase
2)“Sensitive skin care” and atopic dermatitis support treatment through a combined reduction of long TSLP (itching mediator) and bacteriostatic action against the pathogen Staphylococcus Aureus
3) Cytokine modulation in skin cells to counteract environmental aggressive factors ( UV B rays) and the onset of micro circulation unbalance (e g dark circles)
4) Skin wellness increased parameters ( firmness, roughness and redness decrease)
5) Free radicals scavenging action- Key Attributes
Sensitive and atopic skin care Skin damage repair Immune-cosmetics for skin wellness Reduction of itching and redness Hyaluronic acid increase Dark circles prevention Microbiome balancing vs S.Aureus and pathogen biofilm onset ZO 1 tight junction increase Anti-inflammaging Anti pollution Anti-oxidant action Skin barrier integrity increase Soothing - Applications
- Cosmeceuticals & medical device
(gynecological , dermatological treatments vs acne, psoriasis atopic dermatitis , eczema etc.)
- Toiletries & Sanitizers
(soothing and microbiota balancing, specific against irritations on atopic and sensitive skin)
- Skin care and emulsions
(sensitive skin treatments, microbiota balancing, anti aging , skin wellness, anti inflammaging , redness reduction and soothing)
Applications & Uses
- Markets
- Applications
- Personal Hygiene Applications
- Skin Care Applications
- Treatment Product Applications
- Application Fields
- Antiage
- Microbiota Care
- Skin Care
Properties
- Microbiological Values
| Value | Units | Test Method / Conditions | |
| Total Microbe Count | 0 - 100 | UFC/g | Internal |
Technical Details & Test Data
- Kalibome Sensitive Epidermal Targets
Kalibiome postbiotics support skin anti aging properties working at epidermal level by targeting the ZO 1 (zonula occludens 1 TIGHT JUNCTION to promote:
• Skin barrier integrity
• Formation of antipollution shield
• Avoid skin dehydration and TEWL
ZO 1 Tight Junction- Improvement of Skin Barrier
Pathogens significantly affect skin barrier integrity and function inducing a reduction of
TEER Trans Epithelial Electrical Resistance values.
Kalibome Sensitive is able to protect barrier integrity and function (in presence of pathogen as demonstrated by the increased TEER values through disruption of the local microbiota and the related inflammation process.- TSLP Modulation (Dermatitis Itiching Reduction)
Long TSLP ( itching mediator) was identified through immuno staining marked in red color) after biopsy.of atopic dermatitis skin
In lesional skin , its content increases significantly , whereas in healthy skin it is decreases down to 8 fold less
Long isoform of TSLP Thymic Stromal Lymphopoietin ) is a cytokine mainly involved in skin inflammation , itch and skin barrier dysfunction
Short isoform is physiological and anti inflammatory .
KALIBIOME SENSITIVE is able to induce, in human tissues , the switch from the long, pro inflammatory , pruritogenic isoform of TSLP to the anti inflammatory , homeostatic , short one- Microbiota Balance
MICROBIOTA BALANCE: IMMUNE SYSTEM ACTIVITY MODULATION
Kalibiome Sensitive cytokine release modulation is a key feature that allows to keep under control the harmful effects related to microbiota unbalance, infections, exposure to UV-B rays and immune diseases like psoriasis Its specific activity on Interleukin 8 is exploited in cosmetics industry to counteract dark circles onset.
Tests carried out on skin cells comparing the activity of Kalibiome Sensitive vs control
TESTS- Interleukin 10
(anti inflammatory cytokine expressed by skin immune system cells)
- Interleukin 12p40
(pro inflammatory cytokine, actively involved in inflammation and skin immune system diseases)
- Interleukin 6 Interleukin 8 and CCL MCP 1
(pro inflammatory cytokines, Interleukin 8 is actively involved in the formation of dark circles on stressed skin)
- Skin Redness Reduction
a* is a parameter calculated by the Chromameter that increases linearly with erythema
Measurement of percentage variations of a* value were carried out (to assess the change of skin redness 48 and 72 hours after the removal of SLS patches) Kalibiome Sensitive shows significant redness reduction against placebo and non treated area
Skin redness evaluated by Chromameter CR 400, Konica Minolta, after removal of SLS patch applied for 24 h