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Kalichem SRL PHOSPHACTEETH REMINERALIZER

Developed in partnership with the Italian National Research Council (NRC), PHOSPHACTEETH REMINERALIZER is a complex able to activate the in vivo formation of several physiological/biomimetic hydroxyapatite derivatives, natural components of enamel, through a two step activation process catalyzed by the saliva. Initially, the reaction of the complex with saliva leads to the in vivo formation of the Functionalized Amorphous Calcium Phosphate Complex (F-ACP system). The F-ACP system’s interaction with the saliva triggers the formation of Fluoride Hydroxyapatite (more resistant to acid erosion), Calcium and Carbonate Hydroxyapatite (physiological minerals forming tooth enamel and dentin) for a complete remineralizing action.

Functions: Oral Care Agent, Remineralization Agent

Labeling Claims: Palm Oil-free

Benefit Claims: Excellent Adhesive Properties, Remineralizing, Strengthening

Certifications & Compliance: ISO 16128

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Knowde Enhanced TDS

Identification & Functionality

Cosmetic Ingredients Functions

Features & Benefits

Labeling Claims
Product Information

PHOSPHACTEETH REMINERALIZER is a biomimetic active with:

  • Optimized tooth adhesion features (due to its citrate content)
  • Optimized interaction with the tooth
  • Reduced loss of actives due to mouth rinsing

Categories:

Oral Care

Technology

PHOSPHACTEETH Technology:
• Developed through innovative scientific equipment & knowledge of CA/P systems
• Result of the studies of Bio Active and Bio Absorbable compounds
• New generation released control system generated in vivo after the contact with water
CHEMICAL BACKGROUND
PHOSPHACEETH forms in vivo the F-ACP System:

CITRATES coating
AMORPHOUS CALCIUM PHOSPHATE
functionalized with
FLUORIDE
CARBONATES
AMORPHOUS CALCIUM PHOSPHATE
Enamel and dentin
matrix precursor
ACP is converted in vivo in enamel minerals
Structural base for the formation of:

  • New Enamel
  • Carbonate Apatite
  • Fluoride Apatite

Applications & Uses

Application Format
Oral Care Applications
Application Fields

Oral Hygiene

Applications

PAR IS SPECIFIC FOR ANHYDROUS FORMULATIONS
• Toothpaste
• Mouthwash
• Chewing Gum
• Gels
• Polimeric Matrix

Properties

Physical Form
Microbiological Values
ValueUnitsTest Method / Conditions
Total Microbe Count0 - 100UFC/gInternal

Regulatory & Compliance

Certifications & Compliance

Technical Details & Test Data

EX-Vivo Tests

2-SEM IMAGES OF TOOTH TREATED WITH PAR TOOTHPASTE
High Resolution Images Magnification @ 5,00 K
Kalichem SRL PHOSPHACTEETH REMINERALIZER - Ex-Vivo Tests

The tooth treated with PAR shows significant improvement during each phase of the evaluation : after 5 days the surface scratches are filled with the onset of a irregular and hard surface in the prismatic area, after 10 days the entire surface looks much more compact, given the high deposition of crystal phase on it.
High Resolution Images- Magnification @ 15,00 K
Kalichem SRL PHOSPHACTEETH REMINERALIZER - Ex-Vivo Tests - 1

The tooth treated with PAR after 7 days shows filled surface scratches with the onset of a irregular and hard surface. The prisms of hydroxyapatite, clearly visible and highly exposed with the control treatment are covered and strenghtened after PAR treatment
3–SEM IMAGES OF TEETH TREATED WITH LEAVE ON GEL
High Resolution Images- Magnification @ 15,00 K
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The tooth treated with PAR after 7 days shows filled surface scratches with the onset of a irregular and hard surface. The prisms of hydroxyapatite, clearly visible and highly exposed with the control treatment are covered and strengthened after PAR treatment
8-VICKERS MICROHARDNESS
Kalichem SRL PHOSPHACTEETH REMINERALIZER - Ex-Vivo Tests - 2

PAR toothpaste strenghtens more efficiently the enamel in Vickers Microhardness terms
PAR Paste:
110 hv Benchmark: 87 hv