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Laboratoires Expanscience is an independent pharmaceutical and dermo-cosmetics laboratory that is focused on developing and manufacturing innovative osteoarthritis and skincare products. For 40 years, Laboratoires Expanscience has marketed innovative cosmetic active and sensory ingredients of natural origin to the cosmetics industry, and has built a well-earned global reputation for innovation and expertise in the treatment of osteoarthritis and skin health.

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Sweetone® is a concentrate of active molecules obtained by enzymatic hydrolysis of Schizandra berries, with a unique composition of peptides, sugars and hydroxy-acids.As an imperfection corrector, Sweetone® globally modulates the non-specific inflammation (-56% IL-1; -74% Il-6; -37% IL-8  In-vitro tests), limits the vascular inflammation (-72% VEGF, -52% proliferation of endothelial cells after 24h) and reduces the melanin synthesis (-25%). This dual soothing and unifying action is thus recommended to reduce the skin redness (-41,35%) and homogenize the skin complexion (-8,93% of contrast) with 0,5% of Sweetone® (clinical study after 28 days).Sweetone® is originating from a Chinese plant sourcing. This preservative-free powder (on organic Maltodextrin carrier) is approved by Ecocert Greenlife.

Sweetone

Collageneer® is a patented active ingredient derived from white Lupin seeds, rich in Lupeol, active molecule that increases the synthesis of Collagen I. Collageneer® has also a complementary stimulation on the production of a high quality collagen by promoting the synthesis of HSP 47 (Heat Shock Proteins), a Chaperone protein.Thanks to Collageneer® at 2%, after 42 days, the firmness of the skin is improved by 92% and the sagging of the facial contour is reduced by 72% (clinical study, Self-assessment evaluation). After 89 days, the skin elasticity is also improved by 10% (clinical study, Cutometer).Collageneer® is originating from French reasoned farming sourcing. This oil soluble active ingredient is preserved with natural Alpha-Tocopherol.

Collageneer

Soline® BIO is an oily active ingredient rich in unsaponifiables, obtained by molecular distillation (patented process) of Organic Sunflower seed oil. Due to its noble components, Soline® BIO is a moisturizer that offers a dual activity by activating PPARAZ receptor: lipid-replenishing and soothing.After a single application, Soline® BIO at 2% provides 24 hours hydration (clinical study). Moreover, the synthesis of epidermal key lipids is stimulated, in order to strengthen the intercorneocyte cement (Ceramides 1 & 2 and Cerebrosides). Soline® BIO presents also a soothing activity by modulating the inflammatory cascade (inhibition of NFAZºB by 36%).This active ingredient is thus used for the relipidation and restructuring of dry, atopic and mature skins. Soline® BIO is originating from European reasoned farming sourcing. This preservative-free active ingredient is certified by Ecocert Greenlife.

Soline

PIXALIA®, eco-designed active ingredient, is an extract exclusively obtained from the dried leaves of Cleome gynandra, an african plant known for its anti-inflammatory properties. Thanks to its anti-inflammatory and anti-oxidant properties, PIXALIA® normalizes the key parameters of oily, acne-prone skin in acting on the whole iterative cascade of acne. PIXALIA® reduces seborrhea in acting on specific lipids associated with acne, improves quality of sebum and reduces inflammation.

Pixalia

MACALINE® is a new Maca extract for a dreamful silhouette. In acting as slimming, draining and firming agent, MACALINE® offers a complete solution to recover a reshaped silhouette, to reduce cellulite, orange-peel aspect as well as heavy legs feeling. Based on polyphenols of Maca, an energizing and stimulating plant, MACALINE® promotes an optimal fat-shedding in acting on lipolysis, lipogenesis and fibrosis in the hypodermis. Microcirculation and skin firmness are also enhanced thanks to the actions on blood-vessel structure as well as on the key markers of skin firmness.

Macaline

Effipulp® is a patented concentrate of Avocado peptides obtained by biotechnological process. Thanks to Effipulp®s detoxyfying effect (Proteasome and Thioredoxin pathways), the cells recover their functions and their ability to synthetize key molecules. At 0,6%, Effipulp® stimulates the endogenous synthesis of hyaluronic acid by 220% (ex vivo test), ensures good cohesion of the Stratum corneum and restores volume to mature, dehydrated, stressed skins (clinical study).Effipulp® is originating from a South African sustainable sourcing and approved for the formulation of finished products certified by Ecocert Greenlife. This active ingredient is a preservative-free powder (on organic maltodextrin carrier).

Effipulp

α-Lupaline® is an oily active ingredient obtained from an association of Lupin oil and Wheat germ oil unsaponifiables. It is an elastase inhibitor and has an antiradical activity. α-Lupaline® is thus specially recommended for restructuring, nutritional, anti-wrinkle and sun care products.

α-Lupaline

ORMESIA®: your skin ready to fight off IN and OUTdoor pollutants. This new active ingredient based on polyphenols of Maracuja (passion fruit) gives the best tools for your skin to brave IN & OUTdoor pollution without fear! Activating hormesis pathway, a natural self-defense mechanism, ORMESIA® detoxifies & protects the skin from the strong stresses of pollutants and sun. Barrier function, structure and mechanical properties of the skin are preserved. Skin radiance is revealed, accelerated aging process is slowed down.

Ormesia

ALGAENIA® is bioinspired from the ecosystem where this microalga was originally found: as it thrived where the waters are known to be highly inhospitable (pH, heavy metals, ...), the resulting peptides helps the skin endure the extreme conditions of its environment. ALGAENIA® acts as a cocoon for the skin to help it resist against sensitization and allergic reactions while soothing & moisturizing it.

Algaenia

5α-Avocuta® is avocado oil butyl esters that limits excessive sebum secretion of hair by inhibiting 5 alpha-reductase activity. On hair, 5α-Avocuta® limits the desquamation activity by -67% and reduces the greasy appearance by 78% after 3 weeks (rince-off conditions with 1% in a shampoo, clinical study). Its effectiveness is recommended in soothing and sebum-regulating products for hair care. 5α-Avocuta® is a preservative-free active ingredient, originating from African and Latin American sustainable sourcing.

5α-Avocuta®

Collageneer®

ACTIMP® Powder Bio offers new efficacy results that support its photoaging and chronoaging claims. New tests highlight ACTIMP® strengthens the dermal-epidermal junction, protects the key actors of the dermal matrix and restores the skin elasticity and preserves the dynamic properties of the dermis. A Lupin concentrate for a perfect union between dermis and epidermis to preserve skin firmness and tonicity. ACTIMP® Powder Bio is made of 100% Organic Lupine Peptides, Preservative Free.

ACTIMP® Powder Bio

PASSIOLINE® is an unsaponifiables concentrate (notably tocotrienols) produced by a patented molecular distillation process from Maracuja Oil. At the same time the oil is produced, the seeds are doubly valuated by the production of an anti-pollution active ingredient (ORMESIA®).

Passioline®

Pixalia®

Soline® BIO is an oily active ingredient rich in unsaponifiables, obtained by molecular distillation (patented process) of Organic Sunflower seed oil. Due to its noble components, Soline® BIO is a moisturizer that offers a dual activity by activating PPARÎ± receptor: lipid-replenishing and soothing.After a single application, Soline® BIO at 2% provides 24 hours hydration (clinical study). Moreover, the synthesis of epidermal key lipids is stimulated, in order to strengthen the intercorneocyte cement (Ceramides 1 & 2 and Cerebrosides). Soline® BIO presents also a soothing activity by modulating the inflammatory cascade (inhibition of NFÎºB by 36%).This active ingredient is thus used for the relipidation and restructuring of dry, atopic and mature skins.Soline® BIO is originating from European reasoned farming sourcing. This preservative-free active ingredient is certified by Ecocert Greenlife.

Soline® Bio

Effipulp®

Aqualicia® is a concentrate of Acacia macrostachya seed peptides, obtained by enzymatic hydrolysis. As a moisturizer, it stimulates and restores the expression of hydration markers (+56% Filaggrin, + 27% Aquaporin-3, ex-vivo studies after 5 days) and cutaneous barrier constituents (+ 115% Claudin-1, + 39% Transglutaminase activity, in-vitro studies).By these two hydration pathways, Aqualicia® helps redynamizing water flows and also restructures the epidermis, for a dynamic and optimal hydration under stress conditions. Thanks to Aqualicia® at 0,5%, the NMF content is stimulated by 104%, the water content by 129%. Thus, the thickness of the stratum corneum is increased by 123% (clinical study after 29 days, RAMAN spectroscopy measurement)Aqualicia® is originating from African sustainable sourcing. This preservative-free powder (on organic Maltodextrin carrier) is approved by Ecocert Greenlife.

Aqualicia®

Macaline®

Laboratoires Expanscience

Laboratoires Expanscience is an independent pharmaceutical and dermo-cosmetics laboratory that is focused on developing and manufacturing innovative osteoarthritis and skincare products. For 40 years,

Laboratoires Expanscience - Knowde

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Skin Care - Beauty & Care - Personal Care - Laboratoires Expanscience - Knowde

Protect your skin. all day long with our anti-pollution shield. This tin.ted soft cream brought a natural complexion an.d skin radiance to all the urban citizens. Choose your best partner to be up for city pollution. Apply every morning on. face to fight against urban pollution.

SOS City-O My Shield Tinted Urban Care

A soothing skin care that deeply hydrates the skin by maintaining a balance water/Lipids. Hydrating Body Serum is an  effective  moisturizer that should be applied daily on the body. Thanks to the dual moisturizing effect of Aqualicia® & Soliiie®, the skin regains a balanced lipid structure and optimal skin's moisture.

Aqua Re-Source Hydrating Body Serum

A skin care that deeply hydrates the skin and protects it from daily urban strees. Face Moisturizer "Sorbet" is a rejuvenating mask that "Re-Source" the skin. Thanks to Aqualicia® the key markers of hydration are restored and the cutaneous barrier constituents synthesis is stimulated.

Aqua Re-Source Face Moisturizer "Sorbet"

PIXEL PERFECT Anti- Imperfections Complex is  the ideal face care that helps to regain a perfectly homogenous skin by reducing imperfections, with a pixel precision. The	combination of precious active molecules from PIXALIA®/SWEETONE® offers	a dual soothing/unifying effect for a purified and sublimated skin.

Pixel Perfect Anti-Imperfections Complex

A precious serum with firming and tonifying effects to rejuvenate your skin. ACT'n PULP Precious Serum is a firming and plumping Skin Care, to target the sagging skin areas. The combination of natural peptides Actimp®/ Effipulp® provides firmness  and elasticity to the skin.

Act'n Pulp Precious Serum

This soothing and luxurious balm helps reuerse slgns of aging. Thanks to lts gentle comfort and its in.n.ouatLue compositLon. INGEN'YOUTH lnnouatiue Anti-Aging Balm is perfectly adapted for dry and mature skins. 

Ingen'Youth Innovative Anti-Aging Balm

Sebo	Clean is a clear lotion that transforms into rich foam .It gently removes impurities and sebum excess, thanks to 5 a Avocuta@ which regulates seborrhea of the T-zone (forehead, nose, chin). This lotion is thus recommanded for greasy skin. After 3 weeks, the skin is clear and matte.

SEBO-Clean

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