Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Pharma & Nutraceuticals Functions
- Ingredients
- CBD Distillate, Melatonin
- Product Families
- Product Characteristics
Appearance (upon reconstitution in deionized water) : Homogeneous, translucent dispersion free from visible particulate matter.
Features & Benefits
- Benefit Claims (Health)
- Limitations of current CBD and Melatonin products
CBD is completely insoluble in water, poorly dissolves in alcohol and only dissolves well in oil. To be optimally absorbed in the intestines, CBD must be presented as individual molecules to the intestinal epithelial cells responsible for uptake of nutrients. In theory products with oily solutions could achieve this, but in practice the break up of an oil by the intestinal fluid and the process of dispersing it into tiny droplets ready for absorption is not straightforward and there are reports of poor bioavailability and high variability in uptake of CBD from oil products. Although melatonin is more soluble the bioavailability of oral melatonin is still relatively low. This is due to high first-pass clearance in the liver and low absorption in the gastrointestinal tract. Thus, there is a clear need for a product that leads to improved absorption of both active ingredients combined.
- Increased efficacy
Our liposomal CBD & Melatonin supplement makes improved absorption in the gut possible. Liposomes are small, carefully designed phospholipid vesicles that form very stable dispersions in water. The phospholipids constitute a bilayer structure in which the CBD and melatonin molecules can be safely kept dissolved, protecting them from degradative enzymes. In addition, liposomes are more easily absorbed by intestinal epithelial cells compared to non-carrier formulations.
What is more, the liposomal supplements that are engineered by LIPOSOMA contain specific additives based on Vitamin E in the bilayer that further increase liposome stability and help protect its vulnerable contents against oxidation as well as attack of gastric fluids and enzymes. This ensures maximal efficiency in body uptake and therapeutic benefit.
- Product Attributes
What is CBD?
Cannabidiol (CBD) is one of the several natural active ingredients of the Cannabis plant. It differs from tetrahydrocannabinol (THC) in that it lacks the well-known psychoactive effects.
Why is Melatonin added?
Melatonin is a naturally produced hormone that helps maintain normal sleep patterns. Supplementation of melatonin safely and effectively contributes to a faster sleep initiation. In addition, melatonin therapy can help alleviate the symptoms of a jet lag, as people using melatonin report better self-recorded mood ratings and sleep parameters.
- Product Highlights
Highly effective
Our liposomal supplements are superior in terms of effectiveness due to our proprietary formulation process and liposomal technology.
Science Based
Our liposome experts have worked in clinical development of liposomal products, which require the highest quality standards.
Better efficacy
Non-toxicOur liposomes are essentially non-toxic and biologically degradable.
Applications & Uses
- Applications
- Dosage Form
- Food & Nutrition Applications
Properties
- Appearance
- Light yellow to off-red colored powder
- Flavor
- Mildly bittersweet
- Odor
- Sllight scent of cannabis terpenes
- Microbiological Values
- Specifications
- Notes
Microbiological Values: Incubated at 30°C for 48 hours
| Value | Units | Test Method / Conditions | |
| Total Aerobic Colony Count | max. 2000 | cfu/g | — |
| Escherichia Coli | Absent | in 10 g | — |
| Enterobacteriaceae | Absent | in 10 g | — |
| Salmonella | Absent | in 25 g | — |
| Total Yeast and Mold Count | max. 100 | cfu/g | — |
| Value | Units | Test Method / Conditions | |
| pH (Reconstitution in Deionized Water) | 4.0 - 6.5 | — | pH meter |
| Cannabidiol (CBD) | 8 - 13 | mg/g | HPLC |
| THC (Total) | max. 0.03 | % (w/w) | Based on CBD content and raw material specifications |
| Melatonin | 8 - 13 | mg/g | HPLC |
| Fat Free Lecithin | 109 - 219 | mg/g | HPLC |
| Tocopherol (and Derivatives) | min. 5 | mg/g | HPLC |
| Ascorbyl Palmitate | max. 15 | mg/g | HPLC |
| Polysorbate 80 | max. 38 | mg/g | HPLC |
| Histidine | 5 - 9 | mg/g | NA |
| Trehalose | 160 - 240 | mg/g | NA |
| Inulin | 430 - 660 | mg/g | NA |
| Liposome Diameter (upon Reconstitution in Deionized Water) | 150 - 600 | nm | DLS |
| Polydispersity index (upon Reconstitution in Deionized Water) | max. 0.6 | — | DLS |
| Residual Water | max. 2 | % | Electrical conductivity |
| Residual Ethanol | max. 0.01 | % | GC |
Storage & Handling
- Shelf Life
- 2 years
- Instructions and Precautions
- This product is of hygroscopic nature. It should be stored in a tightly closed container in a dry and dark storage place at room temperature.
- Avoid long exposure to air and opening in humid environments.
- Slight variations in color, taste and scent may occur among batches and are related to the source of CBD extract. These variations do not affect the product quality.