Knowde Enhanced TDS
Identification & Functionality
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Highlights
Science
- Society is consistently striving to live longer without showing visible signs of aging. Expression wrinkles are the first lines to appear and become more pronounced with time. Their formation is the result of repeated muscular contractions such as talking, smiling, drinking or smoking.
- BoNT-A injections are a popular dermatological treatment to temporarily smooth moderate to severe frown lines, and has recently been approved to treat de crow’s feet area as well. A small sterile dose of this purified toxin injected in the skin blocks the release of the neurotransmitter ACh as it cleaves the SNAP-25 protein, hence preventing the assembly of the SNARE complex. The nerve signal cannot be relayed, the muscle cannot be contracted and it becomes paralyzed. But such injections need to be applied every six months.
- Argirelox™ peptide acts on the modulation of muscle contraction by reducing ACh release at the synapse, as it competes for a position in the SNARE complex but also blocks the entrance from calcium ions, which is necessary for vesicle fusion with the membrane. This is the perfect complement to injections as it can potentiate and maintain the effect of BoNT-A.
- Benefits
- Complements the effect of BoNT-A between sessions
- Maintains and prolongs wrinkle reduction
- Almost 3 times better than the injection alone
Applications & Uses
- Markets
- Applications
- Use Level
- 10%
- Applications
Argirelox™ peptide is the ideal ingredient to incorporate into facial formulations, especially developed to complement injections between sessions.
Properties
- Appearance
- Translucent solution containing 0.050% Acetyl Hexapeptide-8, 0.025% pentapeptide-18
- Soluble in
- Water
Regulatory & Compliance
- Certifications & Compliance