Knowde Enhanced TDS
Identification & Functionality
- Chemical Family
- INCI Name
- Ingredient Origin
- Technologies
Features & Benefits
- Benefit Claims
- Product Highlights
Science
Telomeres consist of repetitive nucleotide sequences at the end of chromosomes that act as caps to protect the genetic data. With each cell division, telomeres become shorter, leading to a loss in chromosome protection and eventually, to cellular senescence. By adding telomere repeats to the end of chromosomes, the telomerase enzyme complex is key to counteract telomere shortening. However, aging causes telomerase to become less active, causing cells to become senescent. Senescent cells develop characteristic morphological changes, such as a decline in lamin B1, which is an essential factor in DNA replication and repair.
Lapagyl™ advanced botanical ingredient showed in vitro to upregulate key telomerase complex genes and to prevent telomere shortening, while also delaying cellular senescence. When applied on the skin of volunteers, it showed to minimize the appearance of wrinkles, improved skin radiance and moisturization and enhanced skin firmness of the upper eyelid for a youthful and better overall look.- Product Benefits
- The tree of life for skin longevity.
- Preventing telomere shortening and senescence.
- Skin that looks better for longer.
- Sustainability
Eco-extraction technology:
- Low water consumption
- Short process
- Low energy consumption
- Use of natural solvents
- Pollution prevention
- No undesired reactions
Applications & Uses
- Markets
- Color Cosmetic Applications
- Hair Care Applications
- Skin Care Applications
- Use Level
- 2.0 - 3.0%
Properties
- Physical Form
- Appearance
- Clear to slightly hazy liquid
- Soluble in
- Oil
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Tabebuia Impetiginosa Bark Extract | 10 | % | — |
| Natural Origin | 100 | % | ISO 16128 |
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- In Vitro Efficacy
Delayed Cellular Senescence
Significant recovery of the age-induced loss of lamin B1.
Upregulation of Key Telomerase Complex Genes
GAR1: +20.4%
DKC1: +23.4%53.6% Lower Telomere Shortening Induced by Aging
Preventing telomere shortening and cellular senescence in vitro
- In Vivo Efficacy
1. Youthful and Beautiful Appearance
30 women applied a cream with 3% Lapagyl™ advanced botanical ingredient on half face and a placebo cream on the other half, twice a day for 28 days.
Minimized appearance of wrinkles: Assessed through real 3D microtopography imaging system based on fringe projection.
More youthful skin complexion -21.6% crow’s feet wrinkle depth
Skin radiance: Evaluated through the gloss parameter by means of a spectrophotometer.
More glowing skin at the end of the treatment
Moisturization: Obtained through corneometry on the cheek. 17.9% improved skin moisture, which is lost with age
2. Minimized Droopy Eyelid
33 women applied a cream with 2% Lapagyl™ advanced botanical ingredient around one eye and a placebo cream on the other eye, twice a day for 56 days.Skin firmness of the upper eyelid: Assessed by means of cutometry. A vertical line was drawn from the end of the upper eyelid to the eyelid fold, and before and after images were superimposed.
Firmer upper eyelid for a better look Improved skin firmness of the upper eyelid by 7.6%