Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
- Commercial Solution
Amber to brown opaque gel consisting of multivesicular liposomes containing a mixture of cellulite-fighting ingredients.
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Attributes
- Minimizes the appearance of cellulite.
- Encourages microcirculation.
- Provides a slimming appearance effect
Science
Cellulite forms due to fat tissue accumulation and liquid retention, usually in thigh, and when adipocytes increase in size, their membranes become distorted and lose their shape. An uneven distribution of fat and a weakened connective tissue modify the appearance of skin leading to “orange-peel” skin dimples. The failure of the vascular system responsible for circulation and drainage of toxins results in leakage of liquid into the surrounding tissue, which also affects adipocytes. They produce an excess of triglycerides and grow in size, becoming trapped in the connective network. Classical anti-cellulite ingredients are combined in multivesicular liposomes, improving their penetration, with the synergistic effect of GHK in Liporeductyl™ functional ingredient. The tripeptide acts as a scavenger for by-products of lipid peroxidation, enhancing the effectiveness of the other components to fight the appearance of cellulite.
Applications & Uses
- Markets
- Applications
- Use Level
- 7%
Properties
- Dispersible in
- Water
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Test Data
In Vitro Efficacy
Inhibition of Adipocyte Maturation
Human preadipocytes in a cell culture were stimulated to differentiate to adipocytes using a potent mixture of differentiation agents which induces a strong accumulation of fat inside the lipid droplets contained in the preadipocytes. The lipid droplets were visualized by phase contrast microscopy and quantified by image analysis. Number of cells per area and number of differentiated adipocytes were also quantified.
Liporeductyl™ Functional Ingredient targets adipocyte maturation in vitro The number of adipocytes decreased and the total number of lipid droplets and their size were reduced in a dose-dependent manner.
In Vivo Efficacy
Slimming Effect and Minimized Cellulite Appearance
20 women with cellulite, aged between 18 and 70 years old, applied a gel containing 7% LiporeductylTM functional ingredient on buttocks and thighs for 60 days.- Instrumental assessments.
- Buttock and thigh circumference
- Body fat mass and extracellular water
- Buttock and thigh circumference
Measurements were performed by STA/BIA instrument.
- Skin moisture and elasticity
Measurements were performed by corneometry and cutometry, respectively.
2. Video-capillaroscopy
Images of the skin were taken using video-capillaroscopy before and after the test. This technique achieves 200x magnifications of cellulite.
- Buttocks: 15% of patients showed a decrease of 2.0 to 3.0 cm, while 60%, of 0.5 to 1.0 cm. Thighs: 85% of volunteers presented a reduction of 0.5 to 1.0 cm
- 50% of volunteers lost between 0.6 and 1.4 kg in weight, and 60% showed a decrease of 0.5 to 1.6 liters in extracellular water
- Liporeductyl™ functional ingredient enhances skin hydration and elasticity After 60 days moisturizing index increased 9.5% and elasticity 24.4%.
- Improves microcirculation reducing the appearance of cellulite nodules and consequently diminishing the appearance of “orange-peel” skin.
- Instrumental assessments.