Knowde Enhanced TDS
Identification & Functionality
- Carrier
- INCI Name
- Ingredient Origin
- Technologies
Features & Benefits
- Benefit Claims
- Labeling Claims
- Features & Benefits
- Improved oxygenation for healthier-looking skin
- Mimics the Tibetan adaptation to hypoxia
- Yoga-like effect to look and feel better
- Product Highlights
Science : The skin receives oxygen from the atmosphere and from blood vessels to perform its biological functions. With age, cutaneous microcirculation decreases, which impairs oxygenation and creates a hypoxic environment. This leads to a dull and unhealthy skin appearance.
The hypoxia inducible factor alpha (HIF-a) senses oxygen content and helps the skin to adapt. In normal oxygenated environments, HIF-1a and HIF-2a are quickly degraded. Under hypoxia conditions, however, they accumulate in cells to activate the transcription of genes that enhance oxygenation. Scientists discovered an improved system of hypoxia adaptation in the Tibetan population. Specifically, a genetic downregulation of HIF-2a in combination with an upregulation of HIF-1a that allows cells to function despite hypoxia conditions.
Oxylance™ advanced botanical ingredient mimics the Tibetan adaptation to hypoxia on the skin, showing a higher expression of HIF-1a gene and lower expression of HIF-2a gene, which suggests better skin oxygenation. When applied on the skin of volunteers, it increased skin oxygen levels and improved the feeling of happiness, just like yoga. In addition, skin glow, wrinkles, and roughness were also improved, resulting ina visibly better overall appearance.
Applications & Uses
- Markets
- Application Format
- Color Cosmetic Applications
- Skin Care Applications
- Use Level
- 2%
Properties
- Physical Form
- Appearance
- Clear medium to dark amber liquid
- Soluble in
- Water
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Ligustrum Lucidum Seed Extract | 0.6 | % | — |
| Natural Origin | 100 | % | ISO 16128 |
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- In Vitro Efficacy
- Reduced Arginase Activity, Which Increases With Age equivalent to 11 years less
- Prevents Formation of Peroxynitrite, a pro-inflammatory and cytotoxic agent
Result : Mimicking the HIF-10 / HIF-2a Tibetan adaptation to hypoxia on the skin for a better cutaneous oxygenation- In Vivo Efficacy
Achieving A “Yoga Skin” Look
84 women were divided into three groups. The first group applied a mist with 2% Oxylance™ advanced botanical ingredient and the second group applied a placebo mist on the face, twice a day for 28 days. The third group performed a single yoga session and did not apply any product.Yoga-Like Effect
Skin oxygen levels : Oxygen levels on the skin were detected by evaluating changes in the concentration of oxy-hemoglobin molecules.
Emotional well-being : An emotional intelligence software was used to evaluate volunteers’ feeling of happiness.
Result :- Oxylance™ advanced botanical ingredient oxygenates the skin just like yoga
- Improved feeling of happiness similar to a yoga session
Improved Overall Skin AppearanceSkin glow : The luminosity value was determined by analysis of highresolution photographs.
Wrinkles and roughness :Assessed through real 3D microtopography imaging system based on fringe projection.
Result :- More glowing and radiant skin after 28 days
- Minimized crow’s feet and skin roughness by up to 68% and 32%, respectively
- Better and healthierlooking complexion for a “yoga skin” look