Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Features and Benefits
- Epigenetics brought to cosmetics
- Recovery of the stemness potential
- Improved complexion of both younger and older skin
- Reprogramming the skin for a youthful appearance
- Product Highlights
Epigenetic mechanisms control gene activity beyond the information in the DNA sequence and are involved in the regulation of epidermal development. Basal cells of the epidermis (stem and progenitor cells) have the ability to proliferate giving rise to cells that then follow a process of differentiation into mature keratinocytes. In basal cells, the capacity to replenish the tissue is maintained mainly by the transcription factors OCT4, SOX2 and KLF4, markers of stem cells. Activity of these genes is regulated at the epigenetic level by microRNAs. Concretely, miR-145 represses these stem cell transcription factors, causing basal cells to stop dividing and start the process of differentiation. This involves also changes in the levels of characteristic markers, switching from the expression of keratin K14 in basal cells with stemness properties to the production of keratin K10 in suprabasal cells that are in the maturation process.
Reproage™ peptide reduces the levels of the epigenetic regulator miR-145 in skin cells and increases the typical factors of basal cells, suggesting a reactivation of the pool of epidermal progenitors. This could counteract the slowdown in regeneration occurring with age and improve skin properties, with a smoother, more radiant and visually rejuvenated appearance.
Applications & Uses
- Markets
- Applications
- Skin Care Applications
- Use Level
- 2%
Properties
- Appearance
- Translucent solution containing 0.05% Acetyl hexapeptide-8.
- Soluble in
- Water
Regulatory & Compliance
- Certifications & Compliance