Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Highlights
Science
Over the years the adhesion between the epidermal and dermal layers is reduced and causes the loss of skin compactness and tone. The DEJ is the basement membrane that joints the epidermis and the dermis, providing structural support to the skin. It is rich in collagen type IV, proteoglycans and the glycoprotein laminin, which is involved in cell proliferation, migration and adhesion. Epidermal cells are anchored to the underlying basement membrane by multiprotein complexes called hemidesmosomes. Integrins are key components of these complexes, as they interact with anchoring filaments rich in laminin, which in turn bind to collagen type IV. Altogether, these connections provide stability to the DEJ, necessary to keep the skin mechanical properties in good conditions.
serilesine® peptide is an active ingredient that targets key elements in the DEJ of the skin for a reinforced structure. The levels of adhesive proteins and the formation of hemidesmosomes showed an increase, and cell proliferation revealed an increment in vitro. In vivo, an improvement in several parameters was observed which may indicate a firming and redensifying effect on the skin.
- Product Highlights
- 305% synthesis of laminin-5
- 405% expression of α6-integrin
- 19% increased cutaneous density
Applications & Uses
- Markets
- Applications
- Use Level
- 1 - 10%
- Applications
serilesine peptide can be incorporated into cosmetic formulations such as emulsions, gels and serums, where skin restructuring and firming effects are desired.
Properties
- Appearance
- Translucent solution
- Soluble in
- Water
- Specifications
| Value | Units | Test Method / Conditions | |
| Hexapeptide - 10. | 0.05 | % | — |
Regulatory & Compliance
- Certifications & Compliance