Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Pharma & Nutraceuticals Functions
- Ingredients
- Hydroxymethylbutyrate
- Product Families
- CaHMB vs. HMB free acid
CaHMB is mono-hydrated calcium salt combined with HMB to create a powder while HMB free acid is HMB in its pure, gel/liquid form.
Features & Benefits
- Benefit Claims (Health)
- Food Ingredients Features
- Product Highlight
HMB’s liquid free acid form offers greater bioavailability and absorption to maximize muscle health benefits.
MyHMB Clear is the pure, free acid form of HMB. This powerful delivery form is rapidly absorbed, allowing for a higher peak and greater concentration in the blood for maximum results. Additionally, myHMB Clear has greater clearance and utilization by your tissues to maximize benefits.
- Increase strength gains from resistance training by over 200%
- Boost muscle thickness by 200%
- Increase lean mass gain by 250%
- Increase body fat loss by 210%
- Improve recovery from intense training
- Improve aerobic metabolism
Applications & Uses
- Markets
- Applications
- Food & Nutrition Applications
- Dosing and Delivery Timing
The recommended dosage for myHMB Clear is 1,000 milligrams three times per day. We recommend evenly spacing your dosages throughout the day. For optimal benefit when training, consume one serving of myHMB Clear 30 minutes prior to training. This ensures peak levels of HMB in the bloodstream for your training session, maximizing its effectiveness. If you are unable to take myHMB Clear prior to exercise, take a dose immediately after a workout or training session.
- 1,000 Milligrams
- 3x Daily
Technical Details & Test Data
- Clinical Study
For decades, scientists have studied and shown the positive effects of CaHMB on increasing strength, lean mass, and decreasing muscle damage and improving recovery after rigorous exercise. This easily deliverable form of HMB has been the mainstay of HMB used in supplements. In 2009, scientists began studying the kinetics of a liquid delivery form, and in 2011 published results showing faster absorption, increased blood levels of HMB, and increased clearance to tissues. This revolutionary study on the new HMB delivery form resulted in several clinical studies demonstrating safety and efficacy.
- Science and Clinical Research
Mechanism of Action:
MyHMB and myHMB Clear both aid muscle health by decreasing muscle protein breakdown through the ubiquitin-proteasome proteolytic pathway and increasing muscle protein synthesis through the mTOR pathway.Decrease Muscle Protein Breakdown
MyHMB Clear decreases the key regulative components and activity of the ubiquitin-proteasome proteolytic pathway, which results in less muscle protein loss. In a 2013 clinical study, myHMB Clear decreased protein breakdown in muscle by 57% (Wilkinson et al., 2013). While the exact mechanism of the effect on the ubiquitin pathway is not currently known, studies in both animal models and humans have shown the same effect, reduced protein breakdown, which helps maintain more muscle mass.Enhance Muscle Protein Synthesis
MyHMB Clear stimulates muscle protein synthesis through multiple mechanisms, including the mTOR pathway – a key regulatory factor that increases myofibrillar protein synthesis. Myofibrillar proteins control muscle contractions and are responsible for the strength of the contraction.MyHMB Clear has been shown to increase the phosphorylation of mTOR, thus activating the mTOR signaling pathway in muscle. The mTOR then stimulates, or up-regulates, the initiation of protein synthesis in the muscle. Studies have shown that supplementing with myHMB Clear increases protein synthesis up to 70% (Wilkinson et al., 2013), and results in a 12-week study show increases in lean mass of 250% greater than placebo and weight training alone (Wilson et al., 2014).
As a result of these mechanisms, myHMB Clear increases muscle protein in your body to help aid strength, power, improve body composition, aerobic performance, and reduce recovery time.
Clinical Research
Clinical research has shown that supplementing with myHMB Clear during training can improve the effects of weight training and indicators of endurance. Specifically, studies have demonstrated HMB’s potential to improve strength, power, body composition, aerobic performance, and recovery for men, women, young, senior, professional athletes and novices.