Knowde Enhanced TDS
Identification & Functionality
- Carrier
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
Applications & Uses
- Markets
- Treatment Product Applications
Properties
- Appearance
- Clear liquid solution
- Odor
- Characteristic
- Soluble in
- Water
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Additives | None | — | — |
| Dosage | 0.5 | % | — |
| pH Value | 5.5 -7.5 | — | — |
| Protein Content Level | 0.7 - 0.8 | mg/ml | — |
| Recommended Use Level | 0.5 | % | — |
Regulatory & Compliance
- Certifications & Compliance
- Regulatory
EU, FDA, JP, CH, KR
Technical Details & Test Data
- In-Vivo Study
- Skin firming
- Skin texture / roughness
- Elasticity
- Digital photography
Strain origin
The strain was found at the Yosemite National Park (CA) U.S. Rich in biological diversity, it is considered a scientific laboratory of hydrology, geology and glaciology, amongst other sciences. It is home of sequoia groves and other centennial trees.
Culturing yeasts
PH4 Ferment is obtained by high-quality yeasts culture, and developed to give nutrients, vitamins, amino acids and enzymes to skin.
Science applied to strains
PH4 Ferment is treated under optimum cultured conditions to improve skin´s elasticity due to its potent effect on collagen synthesis. PH4 (Prolyl 4-Hydroxylase) enzyme is what makes this yeast unique, because (not only) stimulates collagen fibers synthesis, but also improves their stability. In collagen and other related proteins, PH4 catalyzes 4-hydroxyproline formation which is essential in new-born pro-collagen chain´s tri-dimensional folding and assembly.
Ex-vivo test: effects of skin (reconstructed)
3 days application (10µl 0.5%/skin) + 3 days incubation. Results expressed in type I pro-collagen (blue staining)
In-vitro test: Effects on collagen, elastin &ATP synthesis by HDF*. Cell turnover and protection
In-vivo test: Skin firming effect, elasticity and skin texture. Digital photography
Clinical study design: In-use, pre-established randomized pattern, double-blinded, comparative, placebo-controlled study.
Formulation A (0.5% active) versus Formulation B (placebo) Half-face and neck application, twice daily (morning and evening)
Clinical evaluation: 28 days and 20 subjects (healthy women) 34-69 years old
Evaluation performed using :- Clinical Photography
- FOITS Texture Analysis (Fast Optical In vivo Topography of Human Skin)
- DynaSkin (Firmness and Elasticity Evaluation)
Skin firmness and elasticity analysis (Dynaskin technique):
Protocol: The principle of this technique consists in blowing a pressured-controlled airflow over the skin (2g in this case) in order to cause a deformation in the skin that will be proportional to its firmness (the firmer a tissue the less it is deformed by a constant force). This is carried out during the FOITS analysis, thus obtaining a 3D capture of the deformation.
Conclusions:
9 out of the 11 evaluated parameters presented a statistically significant or very significant improvement after only 28 days, including the main ones for each category, therefore we can conclude thatPH4 Natural Lifting Ferment in a cosmetic formulation improves the firmness, the elasticity and the texture of the skin contributing overall to a better condition of the tissue and an improved appearance.
- Fermentation
It has been well documented that extracts from yeast fermentation have demonstrated wound healing properties Fermentation is one of the best ways to provide our skin with a countless bioavailable molecules. such as amino acids and antioxidants
Note: This fascinating combination of nutrients in the extract improves the firmness, the elasticity and the texture of the skin contributing overall to a better condition of the tissue and an improved appearance, giving your skin the essential for an instant beauty.